PMID- 20971219
OWN - NLM
STAT- MEDLINE
DCOM- 20110519
LR  - 20110131
IS  - 1878-7568 (Electronic)
IS  - 1742-7061 (Linking)
VI  - 7
IP  - 3
DP  - 2011 Mar
TI  - Effects of bioactive glass nanoparticles on the mechanical and biological 
      behavior of composite coated scaffolds.
PG  - 1307-18
LID - 10.1016/j.actbio.2010.10.015 [doi]
AB  - Biphasic calcium phosphates (BCP) scaffolds are widely used for bone tissue 
      regeneration. However, brittleness, low mechanical properties and compromised 
      bioactivities are, at present, their major disadvantages. In this study we coated 
      the struts of a BCP scaffold with a nanocomposite layer consisting of bioactive 
      glass nanoparticles (nBG) and polycaprolactone (PCL) (BCP/PCL-nBG) to enhance its 
      mechanical and biological behavior. The effect of various nBG concentrations 
      (1-90 wt.%) on the mechanical properties and in vitro behavior of the scaffolds 
      was comprehensively examined and compared with that for a BCP scaffold coated 
      with PCL and hydroxyapatite nanoparticles (nHA) (BCP/PCL-nHA) and a BCP scaffold 
      coated with only a PCL layer (BCP/PCL). Introduction of 1-90 wt.% nBG resulted in 
      scaffolds with compressive strengths in the range 0.2-1.45 MPa and moduli in the 
      range 19.3-49.4 MPa. This trend was also observed for BCP/PCL-nHA scaffolds, 
      however, nBG induced even better bioactivity and a faster degradation rate. The 
      maximum compressive strength (increased  approximately 14 times) and modulus (increased  approximately 3 
      times) were achieved when 30 wt.% nBG was added, compared with BCP scaffolds. 
      Moreover, BCP/PCL-nBG scaffolds induced the differentiation of primary human 
      bone-derived cells (HOBs), with significant up-regulation of osteogenic gene 
      expression for Runx2, osteopontin and bone sialoprotein, compared with the other 
      groups.
CI  - Copyright (c) 2010 Acta Materialia Inc. Published by Elsevier Ltd. All rights 
      reserved.
FAU - Roohani-Esfahani, S I
AU  - Roohani-Esfahani SI
AD  - Biomaterials and Tissue Engineering Research Unit, School of Aerospace, 
      Mechanical and Mechatronic Engineering, University of Sydney, Sydney 2006, 
      Australia.
FAU - Nouri-Khorasani, S
AU  - Nouri-Khorasani S
FAU - Lu, Z F
AU  - Lu ZF
FAU - Appleyard, R C
AU  - Appleyard RC
FAU - Zreiqat, H
AU  - Zreiqat H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101110
PL  - England
TA  - Acta Biomater
JT  - Acta biomaterialia
JID - 101233144
RN  - 0 (Biocompatible Materials)
SB  - IM
MH  - *Biocompatible Materials
MH  - Bone and Bones/cytology/metabolism/ultrastructure
MH  - Cell Adhesion
MH  - Cell Differentiation
MH  - Gene Expression Regulation
MH  - *Glass
MH  - Humans
MH  - Microscopy, Electron, Scanning
MH  - *Nanoparticles
MH  - Reverse Transcriptase Polymerase Chain Reaction
EDAT- 2010/10/26 06:00
MHDA- 2011/05/20 06:00
CRDT- 2010/10/26 06:00
PHST- 2010/07/22 00:00 [received]
PHST- 2010/10/14 00:00 [revised]
PHST- 2010/10/18 00:00 [accepted]
PHST- 2010/10/26 06:00 [entrez]
PHST- 2010/10/26 06:00 [pubmed]
PHST- 2011/05/20 06:00 [medline]
AID - S1742-7061(10)00479-4 [pii]
AID - 10.1016/j.actbio.2010.10.015 [doi]
PST - ppublish
SO  - Acta Biomater. 2011 Mar;7(3):1307-18. doi: 10.1016/j.actbio.2010.10.015. Epub 
      2010 Nov 10.