PMID- 20973782
OWN - NLM
STAT- MEDLINE
DCOM- 20110104
LR  - 20220330
IS  - 1528-1167 (Electronic)
IS  - 0013-9580 (Linking)
VI  - 51
IP  - 11
DP  - 2010 Nov
TI  - Assessing the unmet treatment need in partial-onset epilepsy: looking beyond 
      seizure control.
PG  - 2231-40
LID - 10.1111/j.1528-1167.2010.02759.x [doi]
AB  - Patients with resistant epilepsy are often coprescribed multiple medications and 
      are more likely to experience drug-drug interactions and adverse events (AEs). A 
      new generation of antiepileptic drugs (AEDs) has been developed with improved 
      safety/tolerability profiles. To evaluate the unmet treatment needs in epilepsy, 
      a comprehensive search of the English-language literature was conducted on 
      Medline and other databases using the terms "partial epilepsy" and "focal 
      seizure," focusing on newer AEDs. Sixty-nine articles were identified. Most 
      patients experienced AEs, which were generally mild-moderate in severity. 
      Drug-drug interactions existed for 6 of 11 AEDs for which data were available. 
      There is evidence for depressive symptoms being associated with zonisamide, and 
      mood-stabilizing effects were shown for lamotrigine and pregabalin. Levetiracetam 
      and eslicarbazepine improved cognitive function. Vigabatrin may increase the risk 
      of developing psychosis. Health-related quality of life (HRQoL) was inversely 
      correlated with seizure frequency. Discontinuation rates were often high, 
      although treatment retention improved with slower dose titration. Adjunctive 
      therapy with newer AEDs has the potential to enhance HRQoL and treatment 
      continuation in patients with partial epilepsy. There remains room for 
      improvement in the management of epilepsy, and better treatments and longer-term 
      trials are needed to meet the special requirements of refractory patients.
CI  - Wiley Periodicals, Inc. (c) 2010 International League Against Epilepsy.
FAU - Schmitz, Bettina
AU  - Schmitz B
AD  - Stroke Unit and Centre for Epilepsy, Vivantes Humboldt-Klinikum, Berlin, Germany.
FAU - Montouris, Georgia
AU  - Montouris G
FAU - Schauble, Barbara
AU  - Schauble B
FAU - Caleo, Sue
AU  - Caleo S
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Review
DEP - 20101025
PL  - United States
TA  - Epilepsia
JT  - Epilepsia
JID - 2983306R
RN  - 0 (Anticonvulsants)
SB  - IM
MH  - Adult
MH  - Anticonvulsants/*adverse effects/*therapeutic use
MH  - Drug Interactions
MH  - Drug Therapy, Combination
MH  - Epilepsies, Partial/*drug therapy/psychology
MH  - *Health Services Needs and Demand
MH  - Humans
MH  - Quality of Life/psychology
MH  - Risk Factors
EDAT- 2010/10/27 06:00
MHDA- 2011/01/05 06:00
CRDT- 2010/10/27 06:00
PHST- 2010/10/27 06:00 [entrez]
PHST- 2010/10/27 06:00 [pubmed]
PHST- 2011/01/05 06:00 [medline]
AID - 10.1111/j.1528-1167.2010.02759.x [doi]
PST - ppublish
SO  - Epilepsia. 2010 Nov;51(11):2231-40. doi: 10.1111/j.1528-1167.2010.02759.x. Epub 
      2010 Oct 25.