PMID- 20974189
OWN - NLM
STAT- MEDLINE
DCOM- 20110401
LR  - 20131121
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Linking)
VI  - 217
IP  - 1
DP  - 2011 Feb 2
TI  - Effect of the interaction between the serotonin transporter gene and maternal 
      environment on developing mouse brain.
PG  - 188-94
LID - 10.1016/j.bbr.2010.10.020 [doi]
AB  - A number of studies have demonstrated that the common polymorphism in the 
      serotonin transporter gene (5-HTT-LPR) moderates the increased risk for major 
      depression seen in persons exposed to early adverse experiences. Several mouse 
      models of this interaction have been recently established to investigate the 
      increased vulnerability of individuals carrying the 5-HTT-LPR S allele to both 
      early and adult life stressful events. Identifying the immediate effects of an 
      adverse early environment on genetically susceptible individuals is critical to 
      develop effective prevention of its long-term negative consequences of such an 
      interaction. For this purpose we investigated molecular and neurochemical effects 
      promoted by variable amount of maternal care in the brain of developing 
      (postnatal day 10) wild type and heterozygous serotonin transporter knockout 
      mice. Pups experiencing low level of maternal care showed increased levels of 
      brain-derived neurotrophic factor (BDNF) messenger RNA within the hippocampus and 
      primary somato-sensory cortex, and increased 
      alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor binding in 
      hippocampus in comparison with pups experiencing high level of maternal care. 
      Strikingly, only heterozygous serotonin transporter knockout pups experiencing 
      high maternal care showed increased hippocampal levels of serotonin and 
      norepinephrine and decreased serotonin turnover compared to wild-type 
      littermates. These findings support the hypothesis that maternal care affects the 
      development of the hippocampus and primary somato-sensory cortex of individuals 
      characterized by genetic variants of the serotonin transporter.
CI  - Copyright (c) 2010 Elsevier B.V. All rights reserved.
FAU - Carola, Valeria
AU  - Carola V
AD  - European Molecular Biology Laboratory (EMBL), Mouse Biology Unit, Monterotondo, 
      Italy. carola@uniroma1.it
FAU - Pascucci, Tiziana
AU  - Pascucci T
FAU - Puglisi-Allegra, Stefano
AU  - Puglisi-Allegra S
FAU - Cabib, Simona
AU  - Cabib S
FAU - Gross, Cornelius
AU  - Gross C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101023
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Receptors, AMPA)
RN  - 0 (Serotonin Plasma Membrane Transport Proteins)
RN  - 0 (Slc6a4 protein, mouse)
RN  - 333DO1RDJY (Serotonin)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Female
MH  - Heterozygote
MH  - Hippocampus/*metabolism
MH  - Male
MH  - Maternal Behavior/*physiology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Norepinephrine/metabolism
MH  - Receptors, AMPA/metabolism
MH  - Serotonin/metabolism
MH  - Serotonin Plasma Membrane Transport Proteins/*genetics
MH  - Somatosensory Cortex/*metabolism
MH  - Visual Cortex/metabolism
EDAT- 2010/10/27 06:00
MHDA- 2011/04/02 06:00
CRDT- 2010/10/27 06:00
PHST- 2010/08/12 00:00 [received]
PHST- 2010/10/11 00:00 [revised]
PHST- 2010/10/17 00:00 [accepted]
PHST- 2010/10/27 06:00 [entrez]
PHST- 2010/10/27 06:00 [pubmed]
PHST- 2011/04/02 06:00 [medline]
AID - S0166-4328(10)00692-3 [pii]
AID - 10.1016/j.bbr.2010.10.020 [doi]
PST - ppublish
SO  - Behav Brain Res. 2011 Feb 2;217(1):188-94. doi: 10.1016/j.bbr.2010.10.020. Epub 
      2010 Oct 23.