PMID- 20974205
OWN - NLM
STAT- MEDLINE
DCOM- 20110629
LR  - 20221207
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 72
IP  - 2
DP  - 2011 Feb
TI  - Human leukocyte antigen-A, -B, -C, -DRB1 allele and haplotype frequencies in 
      Americans originating from southern Europe: contrasting patterns of population 
      differentiation between Italian and Spanish Americans.
PG  - 144-9
LID - 10.1016/j.humimm.2010.10.017 [doi]
AB  - High-resolution DNA sequencing was used to identify the human leukocyte antigen 
      (HLA) -A, -B, -C, and -DRB1 alleles found in 552 individuals from the United 
      States indicating Southern European (Italian or Spanish) heritage. A total of 46 
      HLA-A, 80 HLA-B, 32 HLA-C, and 50 DRB1 alleles were identified. Frequent alleles 
      included A*02:01:01G (allele frequency = 0.26 in Italian Americans and 0.22 in 
      Spanish Americans); B*07:02:01G (Italian Americans allele frequency = 0.11); 
      B*44:03 (Spanish Americans allele frequency = 0.07); C*04:01:01G and C*07:01:01G 
      (allele frequency = 0.13 and 0.16, respectively, in Italian Americans; 0.15 and 
      0.12, respectively, in Spanish Americans); and DRB1*07:01:01 (allele frequency = 
      0.12 in each population). The action of balancing selection was inferred at the 
      HLA-B and -C loci in both populations. The 
      A*01:01:01G-C*07:01:01G-B*08:01:01G-DRB1*03:01:01 haplotype was the most frequent 
      A-C-B-DRB1 haplotype in Italian Americans (haplotype frequency = 0.049), and was 
      the second most frequent haplotype in Spanish Americans (haplotype frequency = 
      0.021). A*29:02:01-C*16:01:01-B*44:03-DRB1*07:01:01 was the most frequent 
      A-C-B-DRB1 in Spanish Americans (haplotype frequency = 0.023), and was observed 
      at a frequency of 0.015 in Italian Americans. Pairwise F'(st) values measuring 
      the degree of differentiation between these Southern European American 
      populations as well as European and European American populations suggest that 
      Spanish Americans constitute a distinct subset of the European American 
      population, most similar to Mexican Americans, whereas Italian Americans cannot 
      be distinguished from the larger European American population.
CI  - Copyright A(c) 2011 American Society for Histocompatibility and Immunogenetics. 
      Published by Elsevier Inc. All rights reserved.
FAU - Mack, Steven J
AU  - Mack SJ
AD  - Children's Hospital Oakland Research Institute, Oakland, California, USA. 
      sjmack@chori.org
FAU - Tu, Bin
AU  - Tu B
FAU - Yang, Ruyan
AU  - Yang R
FAU - Masaberg, Carly
AU  - Masaberg C
FAU - Ng, Jennifer
AU  - Ng J
FAU - Hurley, Carolyn Katovich
AU  - Hurley CK
LA  - eng
GR  - U01 AI067068/AI/NIAID NIH HHS/United States
GR  - U01 AI067068-05/AI/NIAID NIH HHS/United States
GR  - U01 AI067068-05S1/AI/NIAID NIH HHS/United States
GR  - U01AI067068/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20101023
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (DRB1*01:02:03 antigen)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-C Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Alleles
MH  - Gene Frequency/*genetics
MH  - Genetics, Population
MH  - HLA-A Antigens/*genetics/immunology
MH  - HLA-B Antigens/*genetics/immunology
MH  - HLA-C Antigens/*genetics/immunology
MH  - HLA-DR Antigens/*genetics/immunology
MH  - HLA-DRB1 Chains
MH  - Haplotypes/*genetics
MH  - Hispanic or Latino
MH  - Homozygote
MH  - Humans
MH  - Italy/ethnology
MH  - Leukocytes/immunology
MH  - Linkage Disequilibrium/genetics/immunology
MH  - Registries
MH  - Sequence Analysis, DNA
MH  - United States/epidemiology
MH  - White People
PMC - PMC3045865
MID - NIHMS246688
EDAT- 2010/10/27 06:00
MHDA- 2011/06/30 06:00
PMCR- 2011/08/01
CRDT- 2010/10/27 06:00
PHST- 2010/03/13 00:00 [received]
PHST- 2010/10/03 00:00 [revised]
PHST- 2010/10/19 00:00 [accepted]
PHST- 2010/10/27 06:00 [entrez]
PHST- 2010/10/27 06:00 [pubmed]
PHST- 2011/06/30 06:00 [medline]
PHST- 2011/08/01 00:00 [pmc-release]
AID - S0198-8859(10)00531-8 [pii]
AID - 10.1016/j.humimm.2010.10.017 [doi]
PST - ppublish
SO  - Hum Immunol. 2011 Feb;72(2):144-9. doi: 10.1016/j.humimm.2010.10.017. Epub 2010 
      Oct 23.