PMID- 20974278
OWN - NLM
STAT- MEDLINE
DCOM- 20110518
LR  - 20110214
IS  - 1878-5875 (Electronic)
IS  - 1357-2725 (Linking)
VI  - 43
IP  - 3
DP  - 2011 Mar
TI  - Muscle specific kinase: organiser of synaptic membrane domains.
PG  - 295-8
LID - 10.1016/j.biocel.2010.10.008 [doi]
AB  - Muscle Specific Kinase (MuSK) is a transmembrane tyrosine kinase vital for 
      forming and maintaining the mammalian neuromuscular junction (NMJ: the synapse 
      between motor nerve and skeletal muscle). MuSK expression switches on during 
      skeletal muscle differentiation. MuSK then becomes restricted to the postsynaptic 
      membrane of the NMJ, where it functions to cluster acetylcholine receptors 
      (AChRs). The expression, activation and turnover of MuSK are each regulated by 
      signals from the motor nerve terminal. MuSK forms the core of an emerging 
      signalling complex that can be acutely activated by neural agrin (N-agrin), a 
      heparin sulfate proteoglycan secreted from the nerve terminal. MuSK activation 
      initiates complex intracellular signalling events that coordinate the local 
      synthesis and assembly of synaptic proteins. The importance of MuSK as a synapse 
      organiser is highlighted by cases of autoimmune myasthenia gravis in which MuSK 
      autoantibodies can deplete MuSK from the postsynaptic membrane, leading to 
      complete disassembly of the adult NMJ.
CI  - Copyright (c) 2010 Elsevier Ltd. All rights reserved.
FAU - Ghazanfari, Nazanin
AU  - Ghazanfari N
AD  - Physiology and Bosch Institute, Anderson Stuart Bldg (F13), The University of 
      Sydney, Sydney, NSW 2006, Australia. nazanin@physiol.usyd.edu.au
FAU - Fernandez, Kristine J
AU  - Fernandez KJ
FAU - Murata, Yui
AU  - Murata Y
FAU - Morsch, Marco
AU  - Morsch M
FAU - Ngo, Shyuan T
AU  - Ngo ST
FAU - Reddel, Stephen W
AU  - Reddel SW
FAU - Noakes, Peter G
AU  - Noakes PG
FAU - Phillips, William D
AU  - Phillips WD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20101023
PL  - Netherlands
TA  - Int J Biochem Cell Biol
JT  - The international journal of biochemistry & cell biology
JID - 9508482
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
SB  - IM
MH  - Animals
MH  - Autoimmune Diseases/enzymology
MH  - Humans
MH  - Membrane Microdomains/*metabolism
MH  - Muscles/*enzymology
MH  - Organ Specificity
MH  - Receptor Protein-Tyrosine Kinases/chemistry/*metabolism
MH  - Synaptic Membranes/*metabolism
EDAT- 2010/10/27 06:00
MHDA- 2011/05/19 06:00
CRDT- 2010/10/27 06:00
PHST- 2010/09/23 00:00 [received]
PHST- 2010/10/15 00:00 [revised]
PHST- 2010/10/15 00:00 [accepted]
PHST- 2010/10/27 06:00 [entrez]
PHST- 2010/10/27 06:00 [pubmed]
PHST- 2011/05/19 06:00 [medline]
AID - S1357-2725(10)00353-5 [pii]
AID - 10.1016/j.biocel.2010.10.008 [doi]
PST - ppublish
SO  - Int J Biochem Cell Biol. 2011 Mar;43(3):295-8. doi: 10.1016/j.biocel.2010.10.008. 
      Epub 2010 Oct 23.