PMID- 20974318 OWN - NLM STAT- MEDLINE DCOM- 20110207 LR - 20221207 IS - 1879-114X (Electronic) IS - 0149-2918 (Linking) VI - 32 IP - 9 DP - 2010 Aug TI - Impact of acarbose on carotid intima-media thickness in patients with newly diagnosed impaired glucose tolerance or mild type 2 diabetes mellitus: A one-year, prospective, randomized, open-label, parallel-group study in Japanese adults with established coronary artery disease. PG - 1610-7 LID - 10.1016/j.clinthera.2010.07.015 [doi] AB - OBJECTIVE: This study examined the effect of acarbose therapy on carotid intima-media thickness (IMT) in patients with established coronary artery disease (CAD) who had been newly diagnosed with impaired glucose tolerance (IGT) or mild type 2 diabetes mellitus (T2DM). METHODS: This was a 1-year, prospective, randomized, open-label, parallel-group study in patients with established CAD (>/=50% stenosis on quantitative coronary angiography) who were newly diagnosed with IGT or mild T2DM. IGT was defined as 2-hour glucose concentrations of 140 to 199 mg/dL on the 75-g oral glucose tolerance test (OGTT). Mild T2DM was defined as a fasting plasma glucose concentration <126 mg/dL, 2-hour plasma glucose concentration on OGTT >200 mg/dL, and glycosylated hemoglobin (HbA(1c)) <6.5%. On the day after undergoing coronary angiography, patients were randomly allocated to receive either acarbose 150 mg/d or control (no treatment). Carotid IMT was measured by ultrasonography at baseline and at 12 months of follow-up. The changes in glucose profiles (75-g OGTT), HbA(1c), and lipid profiles were also compared between baseline and follow-up. At visits every 2 months, data on adverse events, drug adherence, and changes in medication were collected. Adverse events were recorded based on spontaneous reports and questioning by the investigator. Clinical follow-up data on outcomes of interest were obtained from patients' hospital charts or from telephone interviews; these outcomes were the incidence of mortality, nonfatal myocardial infarction, repeat percutaneous coronary intervention for a treated coronary artery, and stroke. RESULTS: Ninety Japanese patients were enrolled in the study (45 in each group). Two patients in the acarbose group discontinued therapy due to drug-related diarrhea, and 1 patient in each group was discontinued because of a newly diagnosed malignancy. Three patients in the control group were discontinued because they initiated treatment with fibrates, and 2 patients in the control group were lost to follow-up. Thus, complete baseline and follow-up data were available for 42 patients in the acarbose group and 39 in the control group. These 81 patients were predominantly male (74 [91.4%]), with a mean (SD) age of 66.3 (9.0) years, mean body weight of 65.9 (10.5) kg, and mean HbA(1c) of 5.57% (0.38%). Baseline characteristics appeared to be comparable between the 2 groups. In the acarbose group, IMT increased from a mean of 1.28 (0.53) mm at baseline to 1.30 (0.52) mm at 12-month follow-up (mean change, 0.02 [0.29] mm; P = NS), whereas in the control group, it increased from a mean of 1.15 (0.37) mm to 1.32 (0.46) mm (mean change, 0.17 [0.25] mm; P < 0.001 ). The difference between groups was statistically significant (P = 0.01). In addition, the acarbose group had significant reductions from baseline in 2-hour glucose concentrations on the 75-g OGTT (mean change, -24.8 [45.2] mg/dL; P = 0.001), fasting total cholesterol (mean change, -11.26 [26.1] mg/dL; P = 0.009), and fasting triglyceride concentrations (mean change, -30.4 [62.7] mg/dL; P = 0.003), whereas the corresponding changes were not significant in the control group (mean change, -8.5 [39.4], -6.22 [26.7], and -1.05 [74.2] mg/dL, respectively). Cardiovascular events requiring hospitalization occurred in 4 patients (9.5%) in the acarbose group and 4 patients (10.3%) in the control group. No deaths, nonfatal myocardial infarctions, or strokes occurred in either group over the follow-up period. CONCLUSION: In this small, open-label study in patients with established CAD who were newly diagnosed with IGT or mild T2DM, 12 months of treatment with acarbose was associated with a beneficial effect in terms of preventing the progression of carotid IMT compared with control, although it was not associated with a significant decrease in IMT from baseline. UMIN (University Hospital Medical Information Network) Clinical Trials Registry identifier: UMIN000000544. CI - Copyright (c) 2010 Excerpta Medica Inc. All rights reserved. FAU - Koyasu, Masayoshi AU - Koyasu M AD - Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan. FAU - Ishii, Hideki AU - Ishii H FAU - Watarai, Masato AU - Watarai M FAU - Takemoto, Kenji AU - Takemoto K FAU - Inden, Yasuya AU - Inden Y FAU - Takeshita, Kyosuke AU - Takeshita K FAU - Amano, Tetsuya AU - Amano T FAU - Yoshikawa, Daiji AU - Yoshikawa D FAU - Matsubara, Tatsuaki AU - Matsubara T FAU - Murohara, Toyoaki AU - Murohara T LA - eng PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - United States TA - Clin Ther JT - Clinical therapeutics JID - 7706726 RN - 0 (Blood Glucose) RN - 0 (Glycated Hemoglobin A) RN - 0 (Hypoglycemic Agents) RN - 0 (Lipids) RN - T58MSI464G (Acarbose) SB - IM MH - Acarbose/adverse effects/*pharmacology MH - Aged MH - Blood Glucose/drug effects MH - Carotid Artery, Common/diagnostic imaging/drug effects MH - Coronary Artery Disease/*pathology MH - Diabetes Mellitus, Type 2/drug therapy/pathology MH - Female MH - Follow-Up Studies MH - Glucose Intolerance/drug therapy/pathology MH - Glucose Tolerance Test MH - Glycated Hemoglobin/metabolism MH - Humans MH - Hypoglycemic Agents/adverse effects/*pharmacology MH - Japan MH - Lipids/blood MH - Male MH - Middle Aged MH - Prospective Studies MH - Tunica Intima/diagnostic imaging/*drug effects MH - Ultrasonography EDAT- 2010/10/27 06:00 MHDA- 2011/02/08 06:00 CRDT- 2010/10/27 06:00 PHST- 2010/06/25 00:00 [accepted] PHST- 2010/10/27 06:00 [entrez] PHST- 2010/10/27 06:00 [pubmed] PHST- 2011/02/08 06:00 [medline] AID - S0149-2918(10)00254-7 [pii] AID - 10.1016/j.clinthera.2010.07.015 [doi] PST - ppublish SO - Clin Ther. 2010 Aug;32(9):1610-7. doi: 10.1016/j.clinthera.2010.07.015.