PMID- 20975766
OWN - NLM
STAT- MEDLINE
DCOM- 20101202
LR  - 20170707
IS  - 0386-300X (Print)
IS  - 0386-300X (Linking)
VI  - 64
IP  - 5
DP  - 2010 Oct
TI  - Analysis of reactive oxygen metabolites (ROMs) after cardiovascular surgery as a 
      marker of oxidative stress.
PG  - 323-30
AB  - The transient systemic low perfusion that occurs during cardiovascular surgery 
      leads to oxidative stress and the production of free radicals. A systemic 
      increase of various markers of oxidative stress has been shown to occur during 
      cardiopulmonary bypass (CPB). However, these markers have not been adequately 
      evaluated because they seem to be reactive and short-lived. Here, oxidative 
      stress was measured using the free radical analytical system (FRAS 4) assessing 
      the derivatives of reactive oxygen metabolites (d-ROMs) and biological 
      antioxidant potential (BAP). Blood samples were taken from 21 patients undergoing 
      elective cardiovascular surgery. CPB was used in 15 patients, and abdominal 
      aortic aneurysm (AAA) surgery without CPB was performed in 6. Measurements of 
      d-ROMs and BAP were taken before surgery, 1 day, 1 week, and 2 weeks after 
      surgery, and oxidative stress was evaluated. The d-ROM level increased gradually 
      after cardiovascular surgery up to 2 weeks. Over time, the d-ROM level after 
      surgery involving CPB became higher than that after AAA surgery. This difference 
      reached statistical significance at 1 week and lasted to 2 weeks. The 
      prolongation of CPB was prone to elevate the d-ROM level whereas the duration of 
      the aortic clamp in AAA surgery had no relation to the d-ROM level. The BAP was 
      also elevated after surgery, and was positively correlated with the level of 
      d-ROMs. In this study, patients who underwent cardiovascular surgery involving 
      CPB had significant oxidative damage. The production of ROMs was shown to depend 
      on the duration of CPB. Damage can be reduced if CPB is avoided. When CPB must be 
      used, shortening the CPB time may be effective in reducing oxidative stress.
FAU - Kanaoka, Yuji
AU  - Kanaoka Y
AD  - Division of Vascular Surgery, Department of Surgery, Jikei University, School of 
      Medicine, Minato-ku, Tokyo 105-8461, Japan. yujikana@msn.com
FAU - Inagaki, Ei-ichirou
AU  - Inagaki E
FAU - Hamanaka, Souhei
AU  - Hamanaka S
FAU - Masaki, Hisao
AU  - Masaki H
FAU - Tanemoto, Kazuo
AU  - Tanemoto K
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Japan
TA  - Acta Med Okayama
JT  - Acta medica Okayama
JID - 0417611
RN  - 0 (Biomarkers)
RN  - 0 (Reactive Oxygen Species)
SB  - IM
MH  - Aged
MH  - Aortic Aneurysm/*blood/*surgery
MH  - Biomarkers/blood
MH  - Cardiopulmonary Bypass/adverse effects
MH  - Cardiovascular Surgical Procedures/adverse effects
MH  - Extracorporeal Circulation
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Oxidative Stress/*physiology
MH  - Reactive Oxygen Species/*blood
MH  - Reperfusion Injury/blood
MH  - Retrospective Studies
MH  - Time Factors
MH  - Vascular Diseases/*blood/*surgery
EDAT- 2010/10/27 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/10/27 06:00
PHST- 2010/10/27 06:00 [entrez]
PHST- 2010/10/27 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 10.18926/AMO/40508 [doi]
PST - ppublish
SO  - Acta Med Okayama. 2010 Oct;64(5):323-30. doi: 10.18926/AMO/40508.