PMID- 20976089
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20220330
IS  - 2042-0064 (Electronic)
IS  - 2090-8059 (Print)
IS  - 2042-0064 (Linking)
VI  - 2010
DP  - 2010 May 26
TI  - Osteoporosis syndrome in thalassaemia major: an overview.
PG  - 537673
LID - 10.4061/2010/537673 [doi]
LID - 537673
AB  - Osteoporosis in thalassaemia major (TM) represents a prominent cause of 
      morbidity. The mechanism of pathogenesis of bone disease (BD) in TM is 
      multifactorial and complicated. Peak bone mass is achieved shortly after 
      completion of puberty and normally remains stable until the third decade of life 
      when age-related bone mass begins. Growth hormone (GH) and sex steroids play a 
      crucial role in bone remodeling and in the maintenance of skeletal architecture 
      during adult life. GH and insulin growth factors (IGFs) have anabolic effect in 
      bone formation. Sex steroids act probably by increasing the expression of RANKL 
      by osteoblastic cells and alterations in the RANK/RANKL/OPG system in favor of 
      osteoclasts. Impaired GH secretion and lack of sex steroids in thalassemic 
      patients due to pituitary damage, contribute to failure of achieving optimal peak 
      bone mass. Other endocrine complications such as hypoparathyroidism and vitamin D 
      deficiency have also a detrimental role on bones in TM. It is still questionable 
      whether the international criteria for defining osteopenia and osteoporosis are 
      relevant to patients with TM; also a question arises for the diagnostic methods 
      such as DEXA scan and management of osteoporosis with known treatment protocols, 
      in the thalassaemic patient.
FAU - Toumba, Meropi
AU  - Toumba M
AD  - Paediatric Endocrine Unit, Department of Paediatrics, Makarios Hospital, 1474 
      Nicosia, Cyprus.
FAU - Skordis, Nicos
AU  - Skordis N
LA  - eng
PT  - Journal Article
DEP - 20100526
PL  - United States
TA  - J Osteoporos
JT  - Journal of osteoporosis
JID - 101538878
PMC - PMC2957233
EDAT- 2010/10/27 06:00
MHDA- 2010/10/27 06:01
PMCR- 2010/05/26
CRDT- 2010/10/27 06:00
PHST- 2010/01/15 00:00 [received]
PHST- 2010/03/04 00:00 [accepted]
PHST- 2010/10/27 06:00 [entrez]
PHST- 2010/10/27 06:00 [pubmed]
PHST- 2010/10/27 06:01 [medline]
PHST- 2010/05/26 00:00 [pmc-release]
AID - 10.4061/2010/537673 [doi]
PST - epublish
SO  - J Osteoporos. 2010 May 26;2010:537673. doi: 10.4061/2010/537673.