PMID- 20977948
OWN - NLM
STAT- MEDLINE
DCOM- 20110519
LR  - 20220310
IS  - 1878-7568 (Electronic)
IS  - 1742-7061 (Print)
IS  - 1742-7061 (Linking)
VI  - 7
IP  - 3
DP  - 2011 Mar
TI  - Dendritic cell responses to surface properties of clinical titanium surfaces.
PG  - 1354-63
LID - 10.1016/j.actbio.2010.10.020 [doi]
AB  - Dendritic cells (DCs) play pivotal roles in responding to foreign entities during 
      the innate immune response and in initiating effective adaptive immunity as well 
      as maintaining immune tolerance. The sensitivity of DCs to foreign stimuli also 
      makes them useful cells to assess the inflammatory response to biomaterials. 
      Elucidating material property-DC phenotype relationships using a well-defined 
      biomaterial system is expected to provide criteria for immunomodulatory 
      biomaterial design. Clinical titanium (Ti) substrates, including pretreatment 
      (PT), sand blasted and acid etched (SLA), and modified SLA (modSLA), with 
      different roughnesses and surface energies were used to treat DCs and resulted in 
      differential DC responses. PT and SLA induced a mature DC (mDC) phenotype, while 
      modSLA promoted a non-inflammatory environment by supporting an immature DC (iDC) 
      phenotype, based on surface marker expression, cytokine production profiles and 
      cell morphology. Principal component analysis (PCA) confirmed these experimental 
      results, and also indicated that the non-stimulating property of modSLA covaried 
      with certain surface properties, such as high surface hydrophilicity, percent 
      oxygen and percent Ti of the substrates. In addition to previous research that 
      demonstrated superior osteogenic properties of modSLA compared with PT and SLA, 
      the results reported herein indicates that modSLA may further benefit implant 
      osteointegration by reducing local inflammation and its associated 
      osteoclastogenesis.
CI  - Copyright (c) 2010 Acta Materialia Inc. Published by Elsevier Ltd. All rights 
      reserved.
FAU - Kou, Peng Meng
AU  - Kou PM
AD  - Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of 
      Technology, Atlanta, GA 30332, USA.
FAU - Schwartz, Zvi
AU  - Schwartz Z
FAU - Boyan, Barbara D
AU  - Boyan BD
FAU - Babensee, Julia E
AU  - Babensee JE
LA  - eng
GR  - AR052102/AR/NIAMS NIH HHS/United States
GR  - R01 EB004633/EB/NIBIB NIH HHS/United States
GR  - R01 AR052102/AR/NIAMS NIH HHS/United States
GR  - R01 AR052102-04/AR/NIAMS NIH HHS/United States
GR  - R01 EB004633-04/EB/NIBIB NIH HHS/United States
GR  - EB004633/EB/NIBIB NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20101025
PL  - England
TA  - Acta Biomater
JT  - Acta biomaterialia
JID - 101233144
RN  - 0 (Cytokines)
RN  - D1JT611TNE (Titanium)
SB  - IM
MH  - Cell Differentiation
MH  - Cytokines/metabolism
MH  - Dendritic Cells/*immunology
MH  - Humans
MH  - Microscopy, Electron, Scanning
MH  - Osteoblasts/cytology/metabolism/ultrastructure
MH  - Principal Component Analysis
MH  - Surface Properties
MH  - Titanium/*chemistry
PMC - PMC3031747
MID - NIHMS253674
EDAT- 2010/10/28 06:00
MHDA- 2011/05/20 06:00
PMCR- 2012/03/01
CRDT- 2010/10/28 06:00
PHST- 2010/09/03 00:00 [received]
PHST- 2010/10/13 00:00 [revised]
PHST- 2010/10/20 00:00 [accepted]
PHST- 2010/10/28 06:00 [entrez]
PHST- 2010/10/28 06:00 [pubmed]
PHST- 2011/05/20 06:00 [medline]
PHST- 2012/03/01 00:00 [pmc-release]
AID - S1742-7061(10)00495-2 [pii]
AID - 10.1016/j.actbio.2010.10.020 [doi]
PST - ppublish
SO  - Acta Biomater. 2011 Mar;7(3):1354-63. doi: 10.1016/j.actbio.2010.10.020. Epub 
      2010 Oct 25.