PMID- 20978713
OWN - NLM
STAT- MEDLINE
DCOM- 20110518
LR  - 20131121
IS  - 2567-689X (Electronic)
IS  - 0340-6245 (Linking)
VI  - 105
IP  - 1
DP  - 2011 Jan
TI  - Strenuous physical exercise adversely affects monocyte chemotaxis.
PG  - 122-30
LID - 10.1160/TH10-06-0363 [doi]
AB  - Physical exercise is important for proper cardiovascular function and disease 
      prevention, but it may influence the immune system. We evaluated the effect of 
      strenuous exercise on monocyte chemotaxis. Monocytes were isolated from blood of 
      13 young, healthy, sedentary individuals participating in a three-week training 
      program which consisted of repeated exercise bouts. Monocyte chemotaxis and 
      serological biomarkers were investigated at baseline, after three weeks training 
      and after four weeks recovery. Chemotaxis towards vascular endothelial growth 
      factor-A (VEGF-A) and transforming growth factor-beta1 (TGF-beta1) was completely 
      inhibited immediately after training (p<0.01), and remained so after four weeks 
      recovery. Likewise, monocyte chemoattractant protein-1 (MCP-1)-induced migration 
      declined after training (p<0.01) and improved only partially during the recovery 
      period. MCP-1 serum levels were significantly reduced after four weeks recovery 
      compared to baseline (p<0.01). Total blood antioxidant capacity was enhanced at 
      this time point (p<0.01). Monocyte chemokinesis, TGF-beta1 and nitric oxide serum 
      levels remained unchanged during the study. Strenuous three-week training 
      consisting of repeated exercise bouts in healthy, sedentary individuals reduces 
      monocyte chemotaxis. It remains to be established, whether this is a sound 
      adaptation to increased stimuli or an untoward reaction to overtraining. 
      Nevertheless, the effect remains for several weeks with no exercise.
FAU - Czepluch, Frauke S
AU  - Czepluch FS
AD  - Department of Cardiology, Cardiovascular Research Institute Maastricht University 
      Medical Center, Maastricht, Netherlands.
FAU - Barres, Romain
AU  - Barres R
FAU - Caidahl, Kenneth
AU  - Caidahl K
FAU - Olieslagers, Serve
AU  - Olieslagers S
FAU - Krook, Anna
AU  - Krook A
FAU - Rickenlund, Anette
AU  - Rickenlund A
FAU - Zierath, Juleen R
AU  - Zierath JR
FAU - Waltenberger, Johannes
AU  - Waltenberger J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101026
PL  - Germany
TA  - Thromb Haemost
JT  - Thrombosis and haemostasis
JID - 7608063
RN  - 0 (Chemokine CCL2)
RN  - 0 (Lipids)
RN  - 0 (Transforming Growth Factor beta1)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 31C4KY9ESH (Nitric Oxide)
SB  - IM
CIN - Thromb Haemost. 2011 Mar;105(3):387-9. PMID: 21264444
MH  - Adaptation, Physiological/physiology
MH  - Body Mass Index
MH  - Chemokine CCL2/blood
MH  - *Chemotaxis, Leukocyte
MH  - *Exercise
MH  - Humans
MH  - Lipids/blood
MH  - Monocytes/*physiology
MH  - Nitric Oxide/blood
MH  - Observation
MH  - Respiratory Function Tests
MH  - Transforming Growth Factor beta1/blood
MH  - Vascular Endothelial Growth Factor A/blood
EDAT- 2010/10/28 06:00
MHDA- 2011/05/19 06:00
CRDT- 2010/10/28 06:00
PHST- 2010/06/10 00:00 [received]
PHST- 2010/10/08 00:00 [accepted]
PHST- 2010/10/28 06:00 [entrez]
PHST- 2010/10/28 06:00 [pubmed]
PHST- 2011/05/19 06:00 [medline]
AID - 10-06-0363 [pii]
AID - 10.1160/TH10-06-0363 [doi]
PST - ppublish
SO  - Thromb Haemost. 2011 Jan;105(1):122-30. doi: 10.1160/TH10-06-0363. Epub 2010 Oct 
      26.