PMID- 20979536
OWN - NLM
STAT- MEDLINE
DCOM- 20110610
LR  - 20110315
IS  - 1651-2006 (Electronic)
IS  - 1401-7431 (Linking)
VI  - 45
IP  - 2
DP  - 2011 Apr
TI  - Takotsubo cardiomyopathy in acute coronary syndrome; clinical features and 
      contribution of cardiac magnetic resonance during the acute and convalescent 
      phase.
PG  - 77-85
LID - 10.3109/14017431.2010.531140 [doi]
AB  - OBJECTIVES: Takotsubo cardiomyopathy (TTC) is a diagnostic entity that is 
      increasingly being recognized. Data from cardiac magnetic resonance (CMR) imaging 
      and its impact on differential diagnosis are limited. METHODS AND RESULTS: After 
      26 months, coronary angiography revealed normal coronary arteries and left 
      ventriculography and/or echocardiography left ventricular dysfunction with apical 
      ballooning in 20 patients with acute coronary syndrome (ACS). Four patients were 
      excluded from CMR and in three patients an alternative diagnosis was revealed. 
      Thirteen patients (all female; 60 +/- 8 years) with TTC underwent a multisequential 
      CMR, in which all showed myocardial oedema with an elevated T2 ratio in the 
      apical region (2.4 +/- 0.4; p < 0.001 vs. healthy controls), and five patients an 
      elevated global relative enhancement (gRE; 3.7 +/- 1.4; p < 0.05 vs. healthy 
      controls). No late gadolinium enhancement (LGE) was detected on CMR. Follow-up 
      after 132 +/- 33 days showed a normalized left ventricular ejection fraction, 
      myocardial mass, T2 ratio, and gRE in all patients. CONCLUSIONS: TTC is a small 
      but definite group among patients with ACS and normal coronary arteries. CMR 
      allows differentiating TTC from other causes such as myocarditis and 
      cardiomyopathies, as well as to identify the transient increase of myocardial 
      mass and resolution of myocardial oedema as the systolic dysfunction improves. 
      Therefore, CMR might add valuable information for the differential diagnoses and 
      therapeutic decision-making in patients with suspected TTC.
FAU - Stensaeth, Knut Haakon
AU  - Stensaeth KH
AD  - Department of Radiology, Section of Cardiovascular Radiology, Oslo University 
      Hospital, Ullevaal, Oslo, Norway. k.h.stensath@medisin.uio.no
FAU - Fossum, Eigil
AU  - Fossum E
FAU - Hoffmann, Pavel
AU  - Hoffmann P
FAU - Mangschau, Arild
AU  - Mangschau A
FAU - Skretteberg, Per Torger
AU  - Skretteberg PT
FAU - Klow, Nils Einar
AU  - Klow NE
LA  - eng
PT  - Journal Article
DEP - 20101028
PL  - England
TA  - Scand Cardiovasc J
JT  - Scandinavian cardiovascular journal : SCJ
JID - 9708377
SB  - IM
CIN - Scand Cardiovasc J. 2011 Apr;45(2):67-71. PMID: 21401402
MH  - Acute Coronary Syndrome/*diagnosis
MH  - Adult
MH  - Aged
MH  - Case-Control Studies
MH  - Diagnosis, Differential
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Middle Aged
MH  - Takotsubo Cardiomyopathy/*diagnosis
MH  - Time Factors
EDAT- 2010/10/29 06:00
MHDA- 2011/06/11 06:00
CRDT- 2010/10/29 06:00
PHST- 2010/10/29 06:00 [entrez]
PHST- 2010/10/29 06:00 [pubmed]
PHST- 2011/06/11 06:00 [medline]
AID - 10.3109/14017431.2010.531140 [doi]
PST - ppublish
SO  - Scand Cardiovasc J. 2011 Apr;45(2):77-85. doi: 10.3109/14017431.2010.531140. Epub 
      2010 Oct 28.