PMID- 20979900
OWN - NLM
STAT- MEDLINE
DCOM- 20110203
LR  - 20101028
IS  - 0376-2491 (Print)
IS  - 0376-2491 (Linking)
VI  - 90
IP  - 25
DP  - 2010 Jul 6
TI  - [The correlation between combining 1p/19q LOH and pathology in gliomas].
PG  - 1781-4
AB  - OBJECTIVE: To investigate the frequencies of combining loss of heterozygosity 
      (LOH) of chromosome 1p/19q in gliomas of different pathologies and analyze the 
      clinical factors correlated with combining LOH by logistic regression. METHODS: 
      Tumor samples from 127 glioma patients were collected. The status of 1p and 19q 
      was evaluated by fluorescence in situ hybridization (FISH) and the frequencies of 
      combining 1p/19q LOH in gliomas of different pathologies were analyzed. RESULTS: 
      The frequencies of combining 1p/19q LOH in astrocytic, oligoastrocytic and 
      oligodendroglial tumors were 19.30%, 50.00% and 80.77% respectively. The 
      frequencies of combining 1p/19q LOH in oligoastrocytic and oligodendroglial 
      tumors were higher than those in astrocytic tumors (P < 0.01) and the frequencies 
      of combining 1p/19q LOH in oligodendroglial tumors was higher than those in 
      oligoastrocytic tumors (P < 0.05). The frequencies of 1p/19q LOH in astrocytic, 
      oligoastrocytic and oligodendroglial tumors were 12.28%, 11.36 and 0 
      respectively. There was no significant correlation between combining 1p/19q LOH 
      and age, gender and grade by logistic regression. CONCLUSION: In gliomas, 
      combining 1p/19q LOH is proved to be the most common pattern of chromosome 
      deletion involving 1p or 19q. It is significantly correlated with 
      oligodendroglial component. Combining 1p/19q LOH may be valuable in the 
      diagnosis, treatment and prognostic prediction for glioma with oligodendroglial 
      component.
FAU - Ren, Xiao-hui
AU  - Ren XH
AD  - Beijing Neurosurgical Institute, Beijing 100050, China.
FAU - Cui, Xiang-li
AU  - Cui XL
FAU - Lin, Song
AU  - Lin S
FAU - Wang, Zhong-cheng
AU  - Wang ZC
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Yi Xue Za Zhi
JT  - Zhonghua yi xue za zhi
JID - 7511141
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Chromosomes, Human, Pair 1
MH  - Chromosomes, Human, Pair 19
MH  - Female
MH  - Glioma/*genetics/*pathology
MH  - Humans
MH  - *Loss of Heterozygosity
MH  - Male
MH  - Middle Aged
MH  - Oligodendroglia/pathology
MH  - Oligodendroglioma/genetics/pathology
MH  - Young Adult
EDAT- 2010/10/29 06:00
MHDA- 2011/02/04 06:00
CRDT- 2010/10/29 06:00
PHST- 2010/10/29 06:00 [entrez]
PHST- 2010/10/29 06:00 [pubmed]
PHST- 2011/02/04 06:00 [medline]
PST - ppublish
SO  - Zhonghua Yi Xue Za Zhi. 2010 Jul 6;90(25):1781-4.