PMID- 20979947
OWN - NLM
STAT- MEDLINE
DCOM- 20101221
LR  - 20131121
IS  - 0301-0430 (Print)
IS  - 0301-0430 (Linking)
VI  - 74
IP  - 5
DP  - 2010 Nov
TI  - Resolution of mesangial light chain deposits 3 years after high-dose melphalan 
      with autologous peripheral blood stem cell transplantation.
PG  - 384-8
AB  - A 52-year-old woman was admitted to our hospital for treatment of nephrotic 
      syndrome. Funduscopic findings showed fundal hemorrhage and soft exudates, and 
      serologic analysis showed a monoclonal serum component that was identified as 
      Bence Jones protein-k type. A bone marrow biopsy showed diffuse proliferation of 
      atypical plasma cells, while a renal biopsy showed diffuse and nodular mesangial 
      proliferation. Immunohistochemical staining confirmed the presence of k chains 
      along the glomerular basement membrane and in mesangial areas. The patient was 
      diagnosed as multiple myeloma (Bence Jones k type) with light chain deposition 
      disease (LCDD). After high-dose melphalan and autologous peripheral blood stem 
      cell transplantation (PBSCT), the multiple myeloma and nephrotic syndrome were in 
      complete remission; her renal function was improved, but a renal biopsy performed 
      6 months after PBSCT showed the persistence of diffuse and nodular lesions. By 
      contrast, a renal biopsy performed 3 years later showed complete resolution of 
      the diffuse and nodular mesangial proliferation.
FAU - Harada, K
AU  - Harada K
AD  - First Department of Internal Medicine, Nara Medical University, Nara, Japan.
FAU - Akai, Y
AU  - Akai Y
FAU - Sakan, H
AU  - Sakan H
FAU - Yamaguchi, Y
AU  - Yamaguchi Y
FAU - Nakatani, K
AU  - Nakatani K
FAU - Iwano, M
AU  - Iwano M
FAU - Saito, Y
AU  - Saito Y
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Germany
TA  - Clin Nephrol
JT  - Clinical nephrology
JID - 0364441
RN  - 0 (Antineoplastic Agents, Alkylating)
RN  - 0 (Immunoglobulin Light Chains)
RN  - 9006-99-9 (Bence Jones Protein)
RN  - Q41OR9510P (Melphalan)
SB  - IM
MH  - Antineoplastic Agents, Alkylating/*administration & dosage
MH  - Bence Jones Protein/metabolism
MH  - Biopsy
MH  - Female
MH  - Humans
MH  - Immunoglobulin Light Chains/*metabolism
MH  - Immunohistochemistry
MH  - Kidney Neoplasms/drug therapy/immunology/surgery/*therapy
MH  - Melphalan/*administration & dosage
MH  - Mesangial Cells/*drug effects/immunology
MH  - Middle Aged
MH  - Multiple Myeloma/*drug therapy/immunology/surgery
MH  - Nephrotic Syndrome/immunology/therapy
MH  - *Peripheral Blood Stem Cell Transplantation
MH  - Remission Induction
MH  - Time Factors
MH  - Transplantation Conditioning/*methods
MH  - Transplantation, Autologous
MH  - Treatment Outcome
EDAT- 2010/10/29 06:00
MHDA- 2010/12/22 06:00
CRDT- 2010/10/29 06:00
PHST- 2010/10/29 06:00 [entrez]
PHST- 2010/10/29 06:00 [pubmed]
PHST- 2010/12/22 06:00 [medline]
AID - 8065 [pii]
PST - ppublish
SO  - Clin Nephrol. 2010 Nov;74(5):384-8.