PMID- 20980776
OWN - NLM
STAT- MEDLINE
DCOM- 20110404
LR  - 20101223
IS  - 1424-3911 (Electronic)
IS  - 1424-3903 (Linking)
VI  - 10
IP  - 5
DP  - 2010
TI  - Fatty acid composition of plasma lipid classes in chronic alcoholic pancreatitis.
PG  - 580-5
LID - 10.1159/000289466 [doi]
AB  - BACKGROUND/AIMS: Supplementation of n-3 long-chain polyunsaturated fatty acids 
      (LCPUFA) is considered as adjuvant therapy in acute pancreatitis. We investigated 
      plasma fatty acid status in chronic pancreatitis (CP). METHODS: Patients with 
      alcoholic CP (n = 56, gender: 33/23 male/female, age: 60.0 [14.0] years (median 
      [IQR]), who reported giving up alcohol consumption several years ago and 51 
      control subjects were included into the study. The fatty acid composition of 
      plasma phospholipids (PL), triacylglycerols (TG) and sterol esters (STE) was 
      analyzed. RESULTS: The sum of monounsaturated fatty acids was significantly 
      higher in patients with CP than in controls (PL: 12.83 [3.35] vs. 12.20 [1.95], 
      TG: 40.51 [6.02] vs. 37.52 [5.80], STE: 20.58 [7.22] vs. 17.54 [3.48], CP vs. 
      control, % weight/weight, median [IQR], p < 0.05). Values of arachidonic acid 
      were significantly lower in patients with CP than in controls (PL: 10.57 [3.56] 
      vs. 11.66 [3.25], STE: 8.14 [2.63] vs. 9.24 [2.86], p < 0.05). Values of 
      eicosapentaenoic acid and docosahexaenoic acid did not differ and there was no 
      difference in the ratio of n-3 to n-6 LCPUFA. CONCLUSION: Our present data do not 
      furnish evidence for the supplementation of n-3 LCPUFA to the diet of CP patients 
      in relatively good clinical condition.
CI  - Copyright (c) 2010 S. Karger AG, Basel.
FAU - Marosvolgyi, Tamas
AU  - Marosvolgyi T
AD  - Department of Paediatrics, University of Pecs, Pecs, Hungary.
FAU - Horvath, Gabor
AU  - Horvath G
FAU - Dittrich, Aniko
AU  - Dittrich A
FAU - Cseh, Judit
AU  - Cseh J
FAU - Lelovics, Zsuzsanna
AU  - Lelovics Z
FAU - Szabo, Eva
AU  - Szabo E
FAU - Decsi, Tamas
AU  - Decsi T
FAU - Figler, Maria
AU  - Figler M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101029
PL  - Switzerland
TA  - Pancreatology
JT  - Pancreatology : official journal of the International Association of 
      Pancreatology (IAP) ... [et al.]
JID - 100966936
RN  - 0 (Fatty Acids)
RN  - 0 (Fatty Acids, Omega-3)
RN  - 0 (Lipids)
RN  - 0 (Phospholipids)
SB  - IM
MH  - Aged
MH  - Fatty Acids/*blood
MH  - Fatty Acids, Omega-3/blood/therapeutic use
MH  - Female
MH  - Humans
MH  - Lipids/*blood
MH  - Male
MH  - Middle Aged
MH  - Pancreatitis, Alcoholic/*blood/diet therapy
MH  - Phospholipids/blood
EDAT- 2010/10/29 06:00
MHDA- 2011/04/05 06:00
CRDT- 2010/10/29 06:00
PHST- 2009/10/28 00:00 [received]
PHST- 2010/02/13 00:00 [accepted]
PHST- 2010/10/29 06:00 [entrez]
PHST- 2010/10/29 06:00 [pubmed]
PHST- 2011/04/05 06:00 [medline]
AID - S1424-3903(10)80048-1 [pii]
AID - 10.1159/000289466 [doi]
PST - ppublish
SO  - Pancreatology. 2010;10(5):580-5. doi: 10.1159/000289466. Epub 2010 Oct 29.