PMID- 20981439
OWN - NLM
STAT- MEDLINE
DCOM- 20110210
LR  - 20211020
IS  - 1432-2307 (Electronic)
IS  - 0945-6317 (Print)
IS  - 0945-6317 (Linking)
VI  - 458
IP  - 1
DP  - 2011 Jan
TI  - Chromosome 3p alterations in pancreatic endocrine neoplasia.
PG  - 39-45
LID - 10.1007/s00428-010-1001-x [doi]
AB  - Pancreatic endocrine tumors (PET) are rare neoplasms classified as functioning 
      (F-PET) or non-functioning (NF-PET) according to the presence of a clinical 
      syndrome due to hormonal hypersecretion. PETs show variable degrees of clinical 
      aggressiveness and loss of chromosome 3p has been suggested to be associated with 
      an advanced stage of disease. We assessed chromosome 3p copy number in 113 
      primary PETs and 32 metastases by fluorescence in situ hybridization (FISH) using 
      tissue microarrays. The series included 56 well-differentiated endocrine tumors 
      (WDET), 62 well-differentiated endocrine carcinomas (WDEC), and 6 poorly 
      differentiated endocrine carcinomas (PDEC). Chromosome 3p alterations were found 
      in 23/113 (20%) primary tumors, with losses being predominant over gains (14% vs. 
      6%). Loss of 3p was found in 5/55 (9%) WDET, 11/52 (21%) WDEC, and never in PDEC. 
      Gains of 3p were detected in 4/55 (7%) WDET, no WDEC, but notably in 3/6 (50%) 
      PDEC (OR 23.6; P = 0.003). Metastases were more frequently monosomic for 3p 
      compared to primary tumors (OR 3.6; P = 0.005). Monosomy was significantly 
      associated with larger tumor size, more advanced tumor stage, and metastasis. No 
      association was found with survival. Chromosome 3p copy number alterations are 
      frequent events in advanced stage PET, with gains prevailing in PDEC while losses 
      are more frequent in WDEC, supporting the view that a specific pattern of 
      alterations are involved in these diverse disease subtypes.
FAU - Amato, Eliana
AU  - Amato E
AD  - ARC-NET Center for Applied Research on Cancer, Hospital Concern and University 
      School of Medicine, Verona, Italy.
FAU - Barbi, Stefano
AU  - Barbi S
FAU - Malpeli, Giorgio
AU  - Malpeli G
FAU - Bersani, Samantha
AU  - Bersani S
FAU - Pelosi, Giuseppe
AU  - Pelosi G
FAU - Capelli, Paola
AU  - Capelli P
FAU - Scarpa, Aldo
AU  - Scarpa A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101028
PL  - Germany
TA  - Virchows Arch
JT  - Virchows Archiv : an international journal of pathology
JID - 9423843
RN  - 0 (DNA, Neoplasm)
RN  - 0 (RASSF1 protein, human)
RN  - 0 (Tumor Suppressor Proteins)
RN  - EC 2.3.2.27 (Von Hippel-Lindau Tumor Suppressor Protein)
RN  - EC 6.3.2.- (VHL protein, human)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Chromosomes, Human, Pair 3/*genetics
MH  - DNA Copy Number Variations/*genetics
MH  - DNA, Neoplasm/genetics
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Metastasis/genetics/pathology
MH  - Neoplasm Staging
MH  - Neuroendocrine Tumors/*genetics/pathology
MH  - Pancreatic Neoplasms/*genetics/pathology
MH  - Retrospective Studies
MH  - Tumor Suppressor Proteins/genetics
MH  - Von Hippel-Lindau Tumor Suppressor Protein/genetics
PMC - PMC3016198
EDAT- 2010/10/29 06:00
MHDA- 2011/02/11 06:00
PMCR- 2010/10/28
CRDT- 2010/10/29 06:00
PHST- 2010/08/23 00:00 [received]
PHST- 2010/10/10 00:00 [accepted]
PHST- 2010/09/28 00:00 [revised]
PHST- 2010/10/29 06:00 [entrez]
PHST- 2010/10/29 06:00 [pubmed]
PHST- 2011/02/11 06:00 [medline]
PHST- 2010/10/28 00:00 [pmc-release]
AID - 1001 [pii]
AID - 10.1007/s00428-010-1001-x [doi]
PST - ppublish
SO  - Virchows Arch. 2011 Jan;458(1):39-45. doi: 10.1007/s00428-010-1001-x. Epub 2010 
      Oct 28.