PMID- 21029611
OWN - NLM
STAT- MEDLINE
DCOM- 20120119
LR  - 20101029
IS  - 0529-567X (Print)
IS  - 0529-567X (Linking)
VI  - 45
IP  - 8
DP  - 2010 Aug
TI  - [Characteristics of glucose metabolism in non-obese and obese women with 
      polycystic ovarian syndrome].
PG  - 575-7
AB  - OBJECTIVE: To investigate characteristics of glucose metabolism of non-obese and 
      obese women with polycystic ovary syndrome (PCOS). METHODS: From May 2006 to 
      April 2009, 1928 PCOS patients treated in Reproductive Medicine Center of 
      Shandong Provincial Hospital Affiliated to Shandong University were enrolled in 
      this study, which were divided into 901 cases [body mass index (BMI) >/= 25 kg/m(2)] 
      in obese group and 1027 cases in non-obese (BMI < 25 kg/m(2)) group. The 
      prevalence of type 2 diabetes mellitus (T2DM), oral glucose tolerance test, 
      impaired fasting glucose (IFG), impaired glucose tolerance (IGT) were compared 
      between the two groups. RESULTS: (1) Blood glucose levels: at the time of 
      fasting, 30, 60, 120 and 180 minutes, the levels of glucose were (5.3 +/- 1.1), 
      (9.0 +/- 2.4), (9.3 +/- 4.4), (7.5 +/- 2.8), (5.3 +/- 1.8) mmol/L in obese group and (5.0 
      +/- 0.8), (8.4 +/- 3.5), (8.0 +/- 4.2), (6.5 +/- 3.2), (4.9 +/- 1.6) mmol/L in non-obese 
      group, which all showed statistical difference at every time point (P < 0.01). 
      (2)The level of insulin: at the time of fasting, 30, 60, 120 min, the level of 
      insulin were (13 +/- 7), (81 +/- 51), (102 +/- 65), (83 +/- 63) mU/L in obese group and 
      (8 +/- 5), (57 +/- 35), (62 +/- 44), (46 +/- 39) mU/L in non-obese group, which all 
      showed statistical difference at every time point (P < 0.01). However, at time 
      point of 180 minutes, the level of insulin did not exhibit significantly 
      difference between obese and non-obese group (P > 0.05). (3) The prevalence of 
      abnormal glucose metabolism: the rate of IFG was 4.98% (96/1928). The rate of 
      abnormal glucose tolerance was 23.08% (445/1928). The rate of IGT were 13.05% 
      (134/1027) in non-obese group and 24.20% (218/901) in obese group, which also 
      showed remarkable difference (P < 0.01). The rate of T2DM were 2.53% (26/1027) in 
      non-obese group and 7.44% (67/901) in obese group, which reached significant 
      difference (P < 0.01). CONCLUSION: Abnormal glucose metabolism was observed more 
      frequently in overweight or obese PCOS women.
FAU - Shi, Yu-hua
AU  - Shi YH
AD  - Reproductive Medicine Center of Shandong Provincial Hospital Affiliated to 
      Shandong University, Jinan 250021, China.
FAU - Zhao, Dong-ni
AU  - Zhao DN
FAU - Zhao, Jun-li
AU  - Zhao JL
FAU - You, Li
AU  - You L
FAU - Liu, Hong
AU  - Liu H
FAU - Sun, Mei
AU  - Sun M
FAU - Chen, Zi-jiang
AU  - Chen ZJ
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Fu Chan Ke Za Zhi
JT  - Zhonghua fu chan ke za zhi
JID - 16210370R
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
SB  - IM
MH  - Adult
MH  - Blood Glucose/*metabolism
MH  - Body Mass Index
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/epidemiology/metabolism
MH  - Fasting/blood
MH  - Female
MH  - Glucose Intolerance/epidemiology/metabolism
MH  - Glucose Metabolism Disorders/*blood/epidemiology
MH  - Glucose Tolerance Test
MH  - Humans
MH  - Insulin/blood
MH  - Insulin Resistance
MH  - Obesity/*blood/metabolism
MH  - Polycystic Ovary Syndrome/*blood/metabolism
MH  - Retrospective Studies
EDAT- 2010/10/30 06:00
MHDA- 2012/01/20 06:00
CRDT- 2010/10/30 06:00
PHST- 2010/10/30 06:00 [entrez]
PHST- 2010/10/30 06:00 [pubmed]
PHST- 2012/01/20 06:00 [medline]
PST - ppublish
SO  - Zhonghua Fu Chan Ke Za Zhi. 2010 Aug;45(8):575-7.