PMID- 21029659
OWN - NLM
STAT- MEDLINE
DCOM- 20110725
LR  - 20111117
IS  - 0376-2491 (Print)
IS  - 0376-2491 (Linking)
VI  - 90
IP  - 31
DP  - 2010 Aug 17
TI  - [Polymorphism of HLA-DRB1 and -DQB1 alleles among young women with cervical 
      squamous cell carcinoma and its relation with human papillomavirus type 16 
      infection].
PG  - 2193-7
AB  - OBJECTIVE: To investigate the polymorphism of human leukocyte antigen (HLA)-DRB1 
      and -DQB1 alleles among young women with cervical squamous cell carcinoma (SCC) 
      and elucidate its relationship with human papillomavirus (HPV) type 16 infection. 
      METHODS: From January 2005 to August 2009, 166 women diagnosed with cervical SCC 
      at our hospital were enrolled. These patients were divided into two groups based 
      on age, including 59 cases in young age group (</= 35 yrs) and 107 cases in 
      non-young age group. In the mean time, 50 cases with uterine myoma treated by 
      hysterectomy were selected as controls. HPV 16 DNA in cervical tissues was 
      amplified by polymerase chain reaction (PCR). HLA-DRB1 and -DQB1 typing were 
      carried out by PCR-sequence specific primer (PCR-SSP) and the allele frequencies 
      calculated. RESULTS: (1) The allele frequency of HLA DQB1*0301 at 29.6% was 
      detected among HPV 16 positive cervical SCC cases in young age group. And it was 
      significantly higher than 12.9% of non-young age group (P < 0.05). The allele 
      frequencies of HLA-DRB1*04 and -DRB1*09 were significantly higher among HPV 16 
      negative cervical SCC cases in young age group as compared with non-young age 
      group (14.1%, 26.6% vs 5.9%, 10.5%) (P < 0.05). The HLA-DRB1*07 allele was not 
      detected among HPV 16 negative cervical SCC cases in young age group, But 14 
      cases (9.2%) were detected in non-young age group (P < 0.05). (2) The allele 
      frequencies of HLA-DQB1*0501 at 7.4% and 6.3% respectively were detected among 
      HPV 16 positive and negative cervical SCC cases in the young age group. And they 
      were significantly lower than 25.8% and 20.4% of non-young age group (P < 0.05). 
      CONCLUSION: The distribution patterns of HLA-DRB1 and -DQB1 alleles among young 
      women with cervical SCC are different from those of older ones. And it has 
      something to do with the HPV 16 infection status.
FAU - Hu, Yan
AU  - Hu Y
AD  - Department of Obstetrics & Gynecology, First Affiliated Hospital, Wenzhou Medical 
      College, Wenzhou 325000, China. hywjz123@sina.com
FAU - Zhang, Sheng-hui
AU  - Zhang SH
FAU - Huang, Yong-gang
AU  - Huang YG
FAU - Zhu, Hua
AU  - Zhu H
FAU - Shuai, Ci-xia
AU  - Shuai CX
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Yi Xue Za Zhi
JT  - Zhonghua yi xue za zhi
JID - 7511141
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Alleles
MH  - Carcinoma, Squamous Cell/genetics/*virology
MH  - Female
MH  - Gene Frequency
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Human papillomavirus 16/*pathogenicity
MH  - Humans
MH  - Middle Aged
MH  - Polymorphism, Genetic
MH  - Uterine Cervical Neoplasms/genetics/*virology
MH  - Young Adult
EDAT- 2010/10/30 06:00
MHDA- 2011/07/26 06:00
CRDT- 2010/10/30 06:00
PHST- 2010/10/30 06:00 [entrez]
PHST- 2010/10/30 06:00 [pubmed]
PHST- 2011/07/26 06:00 [medline]
PST - ppublish
SO  - Zhonghua Yi Xue Za Zhi. 2010 Aug 17;90(31):2193-7.