PMID- 21029826
OWN - NLM
STAT- MEDLINE
DCOM- 20101202
LR  - 20161125
IS  - 1879-1913 (Electronic)
IS  - 0002-9149 (Linking)
VI  - 106
IP  - 9
DP  - 2010 Nov 1
TI  - Effect of spironolactone on left ventricular ejection fraction and volumes in 
      patients with class I or II heart failure.
PG  - 1292-6
LID - 10.1016/j.amjcard.2010.06.052 [doi]
AB  - The beneficial effects of spironolactone in chronic heart failure (HF) have been 
      demonstrated in patients with New York Heart Association (NYHA) class III to IV 
      HF. This study examined the effect of spironolactone on left ventricular (LV) 
      function and functional capacity of patients with mild to moderate HF (NYHA class 
      I to II). One hundred sixty-eight patients with NYHA class I to II HF and LV 
      ejection fraction </=40% were randomized to spironolactone or placebo and assessed 
      by echocardiography, gated single-photon emission computed tomography, 
      technetium-99m sestamibi single-photon emission computed tomographic radionuclide 
      ventriculography, and cardiopulmonary exercise testing at baseline and after 6 
      months of treatment. In the spironolactone group LV ejection fraction increased 
      from 35.2 +/- 0.7% to 39.1 +/- 3.5% (p <0.001), with a decrease in LV end-diastolic 
      and end-systolic volumes and myocardial mass and an improvement in LV diastolic 
      filling pattern. Cardiopulmonary exercise testing parameters did not change. In 
      conclusion, administration of spironolactone to patients with NYHA class I to II 
      HF has beneficial effects on LV remodeling and diastolic function.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Vizzardi, Enrico
AU  - Vizzardi E
AD  - Department of Cardiology, University of Brescia, Italy. enrico.vizzardi@tin.it
FAU - D'Aloia, Antonio
AU  - D'Aloia A
FAU - Giubbini, Raffaele
AU  - Giubbini R
FAU - Bordonali, Tania
AU  - Bordonali T
FAU - Bugatti, Silvia
AU  - Bugatti S
FAU - Pezzali, Natalia
AU  - Pezzali N
FAU - Romeo, Alessia
AU  - Romeo A
FAU - Dei Cas, Alessandra
AU  - Dei Cas A
FAU - Metra, Marco
AU  - Metra M
FAU - Dei Cas, Livio
AU  - Dei Cas L
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20100909
PL  - United States
TA  - Am J Cardiol
JT  - The American journal of cardiology
JID - 0207277
RN  - 0 (Biomarkers)
RN  - 0 (Mineralocorticoid Receptor Antagonists)
RN  - 0 (Placebos)
RN  - 0 (Radiopharmaceuticals)
RN  - 27O7W4T232 (Spironolactone)
RN  - 971Z4W1S09 (Technetium Tc 99m Sestamibi)
SB  - IM
MH  - Analysis of Variance
MH  - Biomarkers/blood
MH  - Echocardiography, Doppler
MH  - Exercise Test
MH  - Female
MH  - Heart Failure/diagnostic imaging/*drug therapy/physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Mineralocorticoid Receptor Antagonists/*therapeutic use
MH  - Oxygen Consumption/physiology
MH  - Placebos
MH  - Radiopharmaceuticals
MH  - Single-Blind Method
MH  - Spironolactone/*therapeutic use
MH  - Stroke Volume/*drug effects
MH  - Technetium Tc 99m Sestamibi
MH  - Tomography, Emission-Computed, Single-Photon
MH  - Treatment Outcome
EDAT- 2010/10/30 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/10/30 06:00
PHST- 2010/04/20 00:00 [received]
PHST- 2010/06/15 00:00 [revised]
PHST- 2010/06/15 00:00 [accepted]
PHST- 2010/10/30 06:00 [entrez]
PHST- 2010/10/30 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - S0002-9149(10)01372-X [pii]
AID - 10.1016/j.amjcard.2010.06.052 [doi]
PST - ppublish
SO  - Am J Cardiol. 2010 Nov 1;106(9):1292-6. doi: 10.1016/j.amjcard.2010.06.052. Epub 
      2010 Sep 9.