PMID- 21029863
OWN - NLM
STAT- MEDLINE
DCOM- 20101122
LR  - 20220409
IS  - 1097-4172 (Electronic)
IS  - 0092-8674 (Print)
IS  - 0092-8674 (Linking)
VI  - 143
IP  - 3
DP  - 2010 Oct 29
TI  - Microbial stimulation fully differentiates monocytes to DC-SIGN/CD209(+) 
      dendritic cells for immune T cell areas.
PG  - 416-29
LID - 10.1016/j.cell.2010.09.039 [doi]
AB  - Dendritic cells (DCs), critical antigen-presenting cells for immune control, 
      normally derive from bone marrow precursors distinct from monocytes. It is not 
      yet established if the large reservoir of monocytes can develop into cells with 
      critical features of DCs in vivo. We now show that fully differentiated 
      monocyte-derived DCs (Mo-DCs) develop in mice and DC-SIGN/CD209a marks the cells. 
      Mo-DCs are recruited from blood monocytes into lymph nodes by lipopolysaccharide 
      and live or dead gram-negative bacteria. Mobilization requires TLR4 and its CD14 
      coreceptor and Trif. When tested for antigen-presenting function, Mo-DCs are as 
      active as classical DCs, including cross-presentation of proteins and live 
      gram-negative bacteria on MHC I in vivo. Fully differentiated Mo-DCs acquire DC 
      morphology and localize to T cell areas via L-selectin and CCR7. Thus the blood 
      monocyte reservoir becomes the dominant presenting cell in response to select 
      microbes, yielding DC-SIGN(+) cells with critical functions of DCs.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Cheong, Cheolho
AU  - Cheong C
AD  - Chris Browne Center for Immunology and Immune Diseases, The Rockefeller 
      University, New York, NY 10065, USA. ccheong@rockefeller.edu
FAU - Matos, Ines
AU  - Matos I
FAU - Choi, Jae-Hoon
AU  - Choi JH
FAU - Dandamudi, Durga Bhavani
AU  - Dandamudi DB
FAU - Shrestha, Elina
AU  - Shrestha E
FAU - Longhi, M Paula
AU  - Longhi MP
FAU - Jeffrey, Kate L
AU  - Jeffrey KL
FAU - Anthony, Robert M
AU  - Anthony RM
FAU - Kluger, Courtney
AU  - Kluger C
FAU - Nchinda, Godwin
AU  - Nchinda G
FAU - Koh, Hyein
AU  - Koh H
FAU - Rodriguez, Anthony
AU  - Rodriguez A
FAU - Idoyaga, Juliana
AU  - Idoyaga J
FAU - Pack, Maggi
AU  - Pack M
FAU - Velinzon, Klara
AU  - Velinzon K
FAU - Park, Chae Gyu
AU  - Park CG
FAU - Steinman, Ralph M
AU  - Steinman RM
LA  - eng
GR  - AI40874/AI/NIAID NIH HHS/United States
GR  - R37 AI040045/AI/NIAID NIH HHS/United States
GR  - UL1RR024143/RR/NCRR NIH HHS/United States
GR  - N01AI40045/AI/NIAID NIH HHS/United States
GR  - UL1 RR024143/RR/NCRR NIH HHS/United States
GR  - GM62116/GM/NIGMS NIH HHS/United States
GR  - U54 GM062116/GM/NIGMS NIH HHS/United States
GR  - R01 AI040874/AI/NIAID NIH HHS/United States
GR  - AI40045/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cell
JT  - Cell
JID - 0413066
RN  - 0 (Ccr7 protein, mouse)
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (DC-specific ICAM-3 grabbing nonintegrin)
RN  - 0 (Lectins, C-Type)
RN  - 0 (Lipopolysaccharide Receptors)
RN  - 0 (Receptors, CCR7)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Toll-Like Receptor 4)
RN  - 126880-86-2 (L-Selectin)
SB  - IM
CIN - Cell. 2010 Oct 29;143(3):339-40. PMID: 21029856
CIN - Nat Rev Immunol. 2010 Dec;10(12):808. PMID: 21155170
MH  - Animals
MH  - Antigen Presentation
MH  - Cell Adhesion Molecules/immunology/*metabolism
MH  - *Cell Differentiation
MH  - Dendritic Cells/*cytology/immunology
MH  - Escherichia coli/*immunology
MH  - L-Selectin/immunology
MH  - Lectins, C-Type/immunology/*metabolism
MH  - Lipopolysaccharide Receptors/immunology
MH  - Lymph Nodes/cytology/immunology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred C57BL
MH  - Monocytes/*cytology/immunology
MH  - Receptors, CCR7/immunology
MH  - Receptors, Cell Surface/immunology/*metabolism
MH  - T-Lymphocytes/immunology
MH  - Toll-Like Receptor 4/agonists/immunology
PMC - PMC3150728
MID - NIHMS248536
EDAT- 2010/10/30 06:00
MHDA- 2010/12/14 06:00
PMCR- 2011/10/29
CRDT- 2010/10/30 06:00
PHST- 2010/05/11 00:00 [received]
PHST- 2010/08/10 00:00 [revised]
PHST- 2010/09/23 00:00 [accepted]
PHST- 2010/10/30 06:00 [entrez]
PHST- 2010/10/30 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
PHST- 2011/10/29 00:00 [pmc-release]
AID - S0092-8674(10)01125-6 [pii]
AID - 10.1016/j.cell.2010.09.039 [doi]
PST - ppublish
SO  - Cell. 2010 Oct 29;143(3):416-29. doi: 10.1016/j.cell.2010.09.039.