PMID- 21030035
OWN - NLM
STAT- MEDLINE
DCOM- 20110526
LR  - 20220317
IS  - 1097-6833 (Electronic)
IS  - 0022-3476 (Linking)
VI  - 158
IP  - 4
DP  - 2011 Apr
TI  - Oral food challenges in children with a diagnosis of food allergy.
PG  - 578-583.e1
LID - 10.1016/j.jpeds.2010.09.027 [doi]
AB  - OBJECTIVE: To assess the outcome of oral food challenges in patients placed on 
      elimination diets based primarily on positive serum immunoglobulin E (IgE) 
      immunoassay results. STUDY DESIGN: This is a retrospective chart review of 125 
      children aged 1-19 years (median age, 4 years) evaluated between January 2007 and 
      August 2008 for IgE-mediated food allergy at National Jewish Health and who 
      underwent an oral food challenge. Clinical history, prick skin test results, and 
      serum allergen-specific IgE test results were obtained. RESULTS: The data were 
      summarized for food avoidance and oral food challenge results. Depending on the 
      reason for avoidance, 84%-93% of the foods being avoided were returned to the 
      diet after an oral food challenge, indicating that the vast majority of foods 
      that had been restricted could be tolerated at discharge. CONCLUSIONS: In the 
      absence of anaphylaxis, the primary reliance on serum food-specific IgE testing 
      to determine the need for a food elimination diet is not sufficient, especially 
      in children with atopic dermatitis. In those circumstances, oral food challenges 
      may be indicated to confirm food allergy status.
CI  - Copyright (c) 2011 Mosby, Inc. All rights reserved.
FAU - Fleischer, David M
AU  - Fleischer DM
AD  - Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA.
FAU - Bock, S Allan
AU  - Bock SA
FAU - Spears, Gayle C
AU  - Spears GC
FAU - Wilson, Carla G
AU  - Wilson CG
FAU - Miyazawa, Naomi K
AU  - Miyazawa NK
FAU - Gleason, Melanie C
AU  - Gleason MC
FAU - Gyorkos, Elizabeth A
AU  - Gyorkos EA
FAU - Murphy, James R
AU  - Murphy JR
FAU - Atkins, Dan
AU  - Atkins D
FAU - Leung, Donald Y M
AU  - Leung DY
LA  - eng
PT  - Journal Article
DEP - 20101028
PL  - United States
TA  - J Pediatr
JT  - The Journal of pediatrics
JID - 0375410
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Allergens
MH  - Child
MH  - Child, Preschool
MH  - Dermatitis, Atopic/epidemiology/*immunology
MH  - Female
MH  - Food
MH  - Food Hypersensitivity/*diagnosis/diet therapy/immunology
MH  - Humans
MH  - Immunoassay
MH  - Immunoglobulin E/*blood
MH  - Infant
MH  - Male
MH  - Retrospective Studies
MH  - Young Adult
EDAT- 2010/10/30 06:00
MHDA- 2011/05/27 06:00
CRDT- 2010/10/30 06:00
PHST- 2009/11/24 00:00 [received]
PHST- 2010/08/24 00:00 [revised]
PHST- 2010/09/15 00:00 [accepted]
PHST- 2010/10/30 06:00 [entrez]
PHST- 2010/10/30 06:00 [pubmed]
PHST- 2011/05/27 06:00 [medline]
AID - S0022-3476(10)00787-0 [pii]
AID - 10.1016/j.jpeds.2010.09.027 [doi]
PST - ppublish
SO  - J Pediatr. 2011 Apr;158(4):578-583.e1. doi: 10.1016/j.jpeds.2010.09.027. Epub 
      2010 Oct 28.