PMID- 21030334
OWN - NLM
STAT- MEDLINE
DCOM- 20110503
LR  - 20161125
IS  - 1876-861X (Electronic)
IS  - 1876-861X (Linking)
VI  - 4
IP  - 6
DP  - 2010 Nov-Dec
TI  - Periprocedural safety of 64-detector row coronary computed tomographic 
      angiography: results from the prospective multicenter ACCURACY trial.
PG  - 375-80
LID - 10.1016/j.jcct.2010.08.003 [doi]
AB  - BACKGROUND: Coronary computed tomographic angiography (CCTA) requires iodinated 
      contrast and often atrioventricular nodal blocking agents and nitroglycerin for 
      heart rate lowering and coronary vasodilation, respectively. To date, the 
      periprocedural safety of CCTA is unknown. OBJECTIVES: The purpose of this study 
      was to evaluate the periprocedural safety of CCTA. METHODS: We prospectively 
      evaluated 232 patients with symptomatic chest pain without preexisting renal 
      insufficiency at 16 sites who underwent CCTA as part of the Assessment by 
      Coronary Computed Tomographic Angiography of Individuals Undergoing Invasive 
      Coronary Angiography (ACCURACY) trial. Patients received iodinated contrast, 
      beta-blockers, and nitroglycerin as part of a predefined CCTA protocol. We assessed 
      the rates of adverse events (AEs) related to these agents. RESULTS: As measured 
      by serum creatinine and creatinine clearance, no significant change was observed 
      in renal function from baseline (1.00 +/- 0.19 mg/dL; modification of diet in renal 
      disease [MDRD]: 76.91 +/- 17.96 mL/min/1.73 m(2)) to 48 hours (1.0 +/- 0.2 mg/dL; P = 
      1.00; MDRD change: 0.2 +/- 12.4 mL/min/1.73 m(2); P = 0.83) or at 30 days (1.0 +/- 
      0.2 mg/dL; P = 0.52; MDRD change: -0.9 +/- 16.9 mL/min/1.73 m(2); P = 0.77). Mean 
      systolic blood pressure decreased from baseline (133 +/- 19 mm Hg) at 1 hour (125 +/- 
      17 mm Hg; P < 0.001) and rebounded at 48 hours (133 +/- 17 mm Hg). Mean heart rate 
      decreased from baseline (65 +/- 10 beats/min) at 1 hour (60 +/- 7 beats/min) but rose 
      at 48 hours (69 +/- 11 beats/min; P < 0.001. All patients were asymptomatic from 
      baseline to follow-up. CONCLUSIONS: The performance of CCTA is safe with low 
      rates of AEs.
CI  - (c) 2010 Society of Cardiovascular Computed Tomography. Published by Elsevier Inc. 
      All rights reserved.
FAU - Bell, George W
AU  - Bell GW
AD  - Department of Medicine, Greenberg Division of Cardiology, Weill Medical College 
      of Cornell University, New York, NY 10128, USA.
FAU - Edwardes, Michael
AU  - Edwardes M
FAU - Dunning, Allison M
AU  - Dunning AM
FAU - Glasofer, Sidney
AU  - Glasofer S
FAU - Lin, Fay Y
AU  - Lin FY
FAU - Labounty, Troy M
AU  - Labounty TM
FAU - Delago, Augustin
AU  - Delago A
FAU - Budoff, Matthew J
AU  - Budoff MJ
FAU - Min, James K
AU  - Min JK
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Multicenter Study
DEP - 20100818
PL  - United States
TA  - J Cardiovasc Comput Tomogr
JT  - Journal of cardiovascular computed tomography
JID - 101308347
RN  - 0 (Adrenergic beta-Antagonists)
RN  - 0 (Contrast Media)
RN  - 0 (Vasodilator Agents)
RN  - AYI8EX34EU (Creatinine)
RN  - G59M7S0WS3 (Nitroglycerin)
SB  - IM
MH  - Acute Kidney Injury/etiology
MH  - Adrenergic beta-Antagonists/adverse effects
MH  - Aged
MH  - Bradycardia/etiology
MH  - Contrast Media/*adverse effects
MH  - Coronary Angiography/*adverse effects
MH  - Coronary Artery Disease/*diagnostic imaging
MH  - Creatinine/blood/urine
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Hypotension/etiology
MH  - Male
MH  - Middle Aged
MH  - Nitroglycerin/adverse effects
MH  - Prospective Studies
MH  - Tomography, X-Ray Computed/*adverse effects
MH  - Vasodilator Agents/adverse effects
EDAT- 2010/10/30 06:00
MHDA- 2011/05/04 06:00
CRDT- 2010/10/30 06:00
PHST- 2010/03/06 00:00 [received]
PHST- 2010/07/28 00:00 [revised]
PHST- 2010/08/08 00:00 [accepted]
PHST- 2010/10/30 06:00 [entrez]
PHST- 2010/10/30 06:00 [pubmed]
PHST- 2011/05/04 06:00 [medline]
AID - S1934-5925(10)00466-1 [pii]
AID - 10.1016/j.jcct.2010.08.003 [doi]
PST - ppublish
SO  - J Cardiovasc Comput Tomogr. 2010 Nov-Dec;4(6):375-80. doi: 
      10.1016/j.jcct.2010.08.003. Epub 2010 Aug 18.