PMID- 21030794
OWN - NLM
STAT- MEDLINE
DCOM- 20110207
LR  - 20220409
IS  - 1349-9092 (Electronic)
IS  - 0917-5040 (Print)
IS  - 0917-5040 (Linking)
VI  - 21
IP  - 1
DP  - 2011
TI  - Increased risk of hospitalization related to motor vehicle accidents among people 
      taking zolpidem: a case-crossover study.
PG  - 37-43
AB  - BACKGROUND: Several epidemiological and experimental studies have found a 
      positive association between the risk of motor vehicle accidents (MVAs) and use 
      of zopiclone and benzodiazepines. There is, however, little evidence of any risk 
      of MVA attributable to the use of zolpidem 1 day before such accidents. We 
      attempted to determine whether the use of zolpidem 1 day before is associated 
      with an increased risk of an MVA. METHODS: Using a 1-million-person randomly 
      sampled cohort from the Taiwan National Health Insurance reimbursement database, 
      12 929 subjects were identified as having been hospitalized between 1998 and 2004 
      due to an MVA. Using a case-crossover design, we selected the day before an MVA 
      as the case period for each subject, and the 91st, 182nd, and 273rd days before 
      the case period as 3 retrospective control periods. Conditional logistical 
      regression models were constructed to calculate the odds ratio (OR) of having an 
      MVA and the exposure of zolpidem 1 day before. We calculated doses of 
      benzodiazepines, zopiclone, and zolpidem based on their defined daily dose. 
      RESULTS: The adjusted OR for involvement in an MVA after taking 1 defined daily 
      dose of zolpidem was 1.74 (95% confidence interval: 1.25-2.43). There were also 
      positive effects for different washout periods and cumulative doses at 7, 14, 21, 
      and 28 days before the occurrence of an MVA. CONCLUSIONS: Use of zolpidem 1 day 
      before might be associated with an increased risk of MVA. Thus, precautionary 
      warnings should be provided when prescribing zolpidem.
FAU - Yang, Yao-Hsu
AU  - Yang YH
AD  - Institute of Occupational Medicine and Industrial Hygiene, National Taiwan 
      University College of Public Health, Taipei, Taiwan.
FAU - Lai, Jung-Nien
AU  - Lai JN
FAU - Lee, Chang-Hsing
AU  - Lee CH
FAU - Wang, Jung-Der
AU  - Wang JD
FAU - Chen, Pau-Chung
AU  - Chen PC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101023
PL  - Japan
TA  - J Epidemiol
JT  - Journal of epidemiology
JID - 9607688
RN  - 0 (Hypnotics and Sedatives)
RN  - 0 (Pyridines)
RN  - 7K383OQI23 (Zolpidem)
SB  - IM
MH  - Accidents, Traffic/*statistics & numerical data
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Cross-Over Studies
MH  - Databases, Factual
MH  - Female
MH  - Hospitalization/*statistics & numerical data
MH  - Humans
MH  - Hypnotics and Sedatives/*adverse effects
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - Pyridines/*adverse effects
MH  - Risk
MH  - Taiwan/epidemiology
MH  - Wounds and Injuries/epidemiology/therapy
MH  - Young Adult
MH  - Zolpidem
PMC - PMC3899515
EDAT- 2010/10/30 06:00
MHDA- 2011/02/08 06:00
PMCR- 2011/01/05
CRDT- 2010/10/30 06:00
PHST- 2010/10/30 06:00 [entrez]
PHST- 2010/10/30 06:00 [pubmed]
PHST- 2011/02/08 06:00 [medline]
PHST- 2011/01/05 00:00 [pmc-release]
AID - JST.JSTAGE/jea/JE20090195 [pii]
AID - JE20090195 [pii]
AID - 10.2188/jea.je20090195 [doi]
PST - ppublish
SO  - J Epidemiol. 2011;21(1):37-43. doi: 10.2188/jea.je20090195. Epub 2010 Oct 23.