PMID- 21031025
OWN - NLM
STAT- MEDLINE
DCOM- 20110208
LR  - 20221207
IS  - 1090-0535 (Electronic)
IS  - 1090-0535 (Linking)
VI  - 16
DP  - 2010 Sep 15
TI  - Genotyping HLA-DRB1 and HLA-DQB1 alleles in Japanese patients with normal tension 
      glaucoma.
PG  - 1874-9
AB  - PURPOSE: Normal tension glaucoma (NTG) is a subtype of glaucoma in which 
      intraocular pressure is within the statistically normal range. NTG may be 
      associated with an immune disorder. The aim of this study was to determine 
      whether specific alleles in the human leukocyte antigen (HLA)-DRB1 and HLA-DQB1 
      genes correlated with NTG in Japanese patients. METHODS: We genotyped the 
      HLA-DRB1 and HLA-DQB1 alleles in 113 Japanese patients with NTG and in 184 
      healthy Japanese control subjects using the polymerase chain 
      reaction-sequence-specific oligonucleotide probes (PCR-SSOP) Luminex method. We 
      assessed the allelic diversity in patients and controls. RESULTS: There were no 
      statistically significant differences in the allele frequency of HLADRB1 and 
      HLA-DQB1 between NTG patients and control subjects, and no HLA-DRB1-HLA-DQB1 
      haplotypes demonstrated any significant association with NTG. CONCLUSIONS: Our 
      findings suggest that HLA-DRB1 and HLA-DQB1 polymorphisms have no significant 
      effect on the development of NTG in Japanese patients.
FAU - Suzuki, Misa
AU  - Suzuki M
AD  - Department of Ophthalmology and Visual Science Yokohama City University Graduate 
      School of Medicine, Yokohama, Kanagawa, Japan.
FAU - Meguro, Akira
AU  - Meguro A
FAU - Ota, Masao
AU  - Ota M
FAU - Nomura, Eiichi
AU  - Nomura E
FAU - Kato, Tetsuo
AU  - Kato T
FAU - Nomura, Naoko
AU  - Nomura N
FAU - Kashiwagi, Kenji
AU  - Kashiwagi K
FAU - Mabuchi, Fumihiko
AU  - Mabuchi F
FAU - Iijima, Hiroyuki
AU  - Iijima H
FAU - Kawase, Kazuhide
AU  - Kawase K
FAU - Yamamoto, Tetsuya
AU  - Yamamoto T
FAU - Nakamura, Makoto
AU  - Nakamura M
FAU - Negi, Akira
AU  - Negi A
FAU - Sagara, Takeshi
AU  - Sagara T
FAU - Nishida, Teruo
AU  - Nishida T
FAU - Inatani, Masaru
AU  - Inatani M
FAU - Tanihara, Hidenobu
AU  - Tanihara H
FAU - Aihara, Makoto
AU  - Aihara M
FAU - Araie, Makoto
AU  - Araie M
FAU - Fukuchi, Takeo
AU  - Fukuchi T
FAU - Abe, Haruki
AU  - Abe H
FAU - Higashide, Tomomi
AU  - Higashide T
FAU - Sugiyama, Kazuhisa
AU  - Sugiyama K
FAU - Kanamoto, Takashi
AU  - Kanamoto T
FAU - Kiuchi, Yoshiaki
AU  - Kiuchi Y
FAU - Iwase, Aiko
AU  - Iwase A
FAU - Ohno, Shigeaki
AU  - Ohno S
FAU - Inoko, Hidetoshi
AU  - Inoko H
FAU - Mizuki, Nobuhisa
AU  - Mizuki N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100915
PL  - United States
TA  - Mol Vis
JT  - Molecular vision
JID - 9605351
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adult
MH  - *Alleles
MH  - Asian People/*genetics
MH  - Female
MH  - Gene Frequency/genetics
MH  - Glaucoma/*genetics
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Haplotypes/genetics
MH  - Humans
MH  - Japan
MH  - Male
MH  - Middle Aged
MH  - Young Adult
PMC - PMC2956698
EDAT- 2010/10/30 06:00
MHDA- 2011/02/09 06:00
PMCR- 2010/01/01
CRDT- 2010/10/30 06:00
PHST- 2010/07/27 00:00 [received]
PHST- 2010/09/09 00:00 [accepted]
PHST- 2010/10/30 06:00 [entrez]
PHST- 2010/10/30 06:00 [pubmed]
PHST- 2011/02/09 06:00 [medline]
PHST- 2010/01/01 00:00 [pmc-release]
AID - 203 [pii]
AID - 2010MOLVIS0303 [pii]
PST - epublish
SO  - Mol Vis. 2010 Sep 15;16:1874-9.