PMID- 21031548
OWN - NLM
STAT- MEDLINE
DCOM- 20110214
LR  - 20211203
IS  - 1527-6473 (Electronic)
IS  - 1527-6465 (Print)
IS  - 1527-6465 (Linking)
VI  - 16
IP  - 11
DP  - 2010 Nov
TI  - Primary sclerosing cholangitis in genetically diverse populations listed for 
      liver transplantation: unique clinical and human leukocyte antigen associations.
PG  - 1324-30
LID - 10.1002/lt.22161 [doi]
AB  - Primary sclerosing cholangitis (PSC) is well characterized in European 
      populations. We aimed to characterize clinical characteristics and human 
      leukocyte antigen (HLA) associations in a population of European American, 
      Hispanic, and African American PSC patients listed for liver transplantation 
      (LT). Population-stratified demographic, clinical, and HLA data from 6767 LT 
      registrants of the United Network for Organ Sharing who had a diagnosis of PSC 
      (4.7% of the registrants) were compared to data from registrants with other 
      diagnoses. Compared to European Americans and Hispanics, African Americans were 
      significantly younger (46.6 +/- 13.7, 42.3 +/- 15.9, and 39.7 +/- 13.1 years, 
      respectively; P = 0.002) and were listed with a higher Model for End-Stage Liver 
      Disease score (15.2 +/- 7.5, 14.9 +/- 7.6, and 18.1 +/- 9.3, respectively; P = 0.001); 
      they were also less frequently noted to have inflammatory bowel disease in 
      comparison with European Americans (71.4% versus 60.5%, P < 0.01). In 
      multivariate analysis, African origin was a significant factor associated with 
      listing for LT with PSC (odds ratio with respect to European Americans = 1.325, 
      95% confidence interval = 1.221-1.438). HLA associations in European Americans, 
      Hispanics, and African Americans with PSC versus alcoholic liver disease were 
      detected for HLA-B8, HLA-DR13, and protective HLA-DR4. However, HLA-DR3, which is 
      in linkage disequilibrium with HLA-B8, showed associations only in European 
      Americans and Hispanics. In conclusion, African Americans with PSC who are listed 
      for LT differ clinically from European Americans and Hispanics. The association 
      with HLA-B8 but not HLA-DR3 in African Americans should make possible the 
      refinement of the HLA associations in PSC.
CI  - (c) 2010 AASLD.
FAU - Bowlus, Christopher L
AU  - Bowlus CL
AD  - Division of Gastroenterology and Hepatology, University of California Davis, 
      Davis, CA 95817, USA. clbowlus@ucdavis.edu
FAU - Li, Chin-Shang
AU  - Li CS
FAU - Karlsen, Tom H
AU  - Karlsen TH
FAU - Lie, Benedicte A
AU  - Lie BA
FAU - Selmi, Carlo
AU  - Selmi C
LA  - eng
GR  - UL1 RR024146/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Liver Transpl
JT  - Liver transplantation : official publication of the American Association for the 
      Study of Liver Diseases and the International Liver Transplantation Society
JID - 100909185
RN  - 0 (HLA-B8 Antigen)
RN  - 0 (HLA-DR Antigens)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Alleles
MH  - Case-Control Studies
MH  - *Cholangitis, Sclerosing/complications/ethnology/genetics/immunology
MH  - Colitis, Ulcerative/etiology/genetics/immunology
MH  - *Ethnicity
MH  - Female
MH  - *Genetic Predisposition to Disease/ethnology
MH  - Genetic Variation
MH  - HLA-B8 Antigen/genetics/immunology
MH  - HLA-DR Antigens/genetics/immunology
MH  - Haplotypes
MH  - Histocompatibility Testing
MH  - Humans
MH  - Inflammatory Bowel Diseases/etiology/genetics/immunology
MH  - Linkage Disequilibrium
MH  - Liver Diseases/complications/genetics/immunology/surgery
MH  - *Liver Transplantation/immunology
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
PMC - PMC2967453
MID - NIHMS226396
EDAT- 2010/10/30 06:00
MHDA- 2011/02/15 06:00
PMCR- 2011/11/01
CRDT- 2010/10/30 06:00
PHST- 2010/10/30 06:00 [entrez]
PHST- 2010/10/30 06:00 [pubmed]
PHST- 2011/02/15 06:00 [medline]
PHST- 2011/11/01 00:00 [pmc-release]
AID - 10.1002/lt.22161 [doi]
PST - ppublish
SO  - Liver Transpl. 2010 Nov;16(11):1324-30. doi: 10.1002/lt.22161.