PMID- 21033620
OWN - NLM
STAT- MEDLINE
DCOM- 20101123
LR  - 20161026
IS  - 0006-9248 (Print)
IS  - 0006-9248 (Linking)
VI  - 111
IP  - 8
DP  - 2010
TI  - MCP-1 -2518 A/G gene polymorphism is associated with blood pressure in ischemic 
      heart disease asymptomatic subjects.
PG  - 420-5
AB  - Monocyte chemoattractant protein-1 (MCP-1), one of the key inflammatory 
      chemokines, plays an important role in the initiation of atherosclerosis, and 
      represents a risk for coronary artery disease and myocardial infarction. A recent 
      animal study showed that MCP-1 gene might be a candidate gene for salt-sensitive 
      hypertension in Dahl salt sensitive rats. This effect has not been yet studied in 
      asymptomatic humans. We tested the MCP-1 -2518 A/G single nucleotide polymorphism 
      (SNP) in 66 hypertensive ischemic heart disease asymptomatic subjects. 
      Inflammatory markers, classic risk factors and absolute cardiovascular risk 
      (SCORE system) were also investigated in these subjects. Our results showed that 
      both, systolic and diastolic values of blood pressure were associated with MCP-1 
      -2518 A/G SNP at the level of both, genotype and allele frequencies. Subjects 
      with mutant G allele had higher levels of both values of blood pressure, systolic 
      (p = 0.035) and diastolic (p = 0.040) than subjects with allele A. Statistically 
      significantly higher levels of both values of blood pressure, systolic (p = 
      0.037) and diastolic (p = 0.021) were found also in IHD asymptomatic subjects 
      with AG and GG genotypes. Subjects with AG and GG genotypes had also an increased 
      absolute cardiovascular risk (1.62% vs 3.17%; p = 0.004) and an increasing trend 
      for elevated plasma level of high-sensitive CRP (2.858 vs 2.062 mg/l; p = 0.076). 
      We did not find any significant correlation between the serum level of MCP-1 and 
      blood pressure. To our best knowledge, this is the first study concerning the 
      association between MCP-1 polymorphism and arterial blood pressure in IHD 
      asymptomatic subjects. These results indicate that the expression of MCP-1 may be 
      increased before the onset of hypertension but further observations from larger 
      cohorts are needed to confirm this finding (Tab. 6, Ref. 41).
FAU - Penz, P
AU  - Penz P
AD  - 1st Department of Internal Medicine, Faculty of Medicine, Comenius University, 
      Bratislava, Slovakia. pnzptr@gmail.com
FAU - Bucova, M
AU  - Bucova M
FAU - Lietava, J
AU  - Lietava J
FAU - Blazicek, P
AU  - Blazicek P
FAU - Paulovicova, E
AU  - Paulovicova E
FAU - Mrazek, F
AU  - Mrazek F
FAU - Bernadic, M
AU  - Bernadic M
FAU - Buckingham, T A
AU  - Buckingham TA
FAU - Petrek, M
AU  - Petrek M
LA  - eng
PT  - Journal Article
PL  - Slovakia
TA  - Bratisl Lek Listy
JT  - Bratislavske lekarske listy
JID - 0065324
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Adult
MH  - Blood Pressure/*genetics
MH  - Chemokine CCL2/*genetics
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Hypertension/complications/*genetics/physiopathology
MH  - Male
MH  - Middle Aged
MH  - Myocardial Ischemia/complications/diagnosis/*genetics/physiopathology
MH  - *Polymorphism, Single Nucleotide
EDAT- 2010/11/03 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/11/02 06:00
PHST- 2010/11/02 06:00 [entrez]
PHST- 2010/11/03 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
PST - ppublish
SO  - Bratisl Lek Listy. 2010;111(8):420-5.