PMID- 21034543
OWN - NLM
STAT- MEDLINE
DCOM- 20110308
LR  - 20101101
IS  - 2542-5641 (Electronic)
IS  - 0366-6999 (Linking)
VI  - 123
IP  - 17
DP  - 2010 Sep
TI  - Pregnancy outcomes in women with heart disease.
PG  - 2324-30
AB  - BACKGROUND: As the Shanghai Obstetrical Cardiology Intensive Care Center, our 
      hospital has accumulated a large number of clinical data of pregnant women with 
      heart disease. This paper is a retrospective analysis of 1142 pregnancies in 
      women with heart disease so as to evaluate the maternal and fetal outcomes of 
      these patients. METHODS: A retrospective analysis was carried out for pregnancies 
      in 1142 women with heart disease who delivered in Shanghai Obstetrical Cardiology 
      Intensive Care Center between 1993 and 2007. RESULTS: In this study, main heart 
      diseases in pregnancy were arrhythmia (n = 359, 31.4%), congenital heart disease 
      (CHD; n = 291, 25.5%), and myocarditis and its sequelae (n = 284, 24.9%); based 
      on the functional classification criteria of New York Heart Association (NYHA), 
      more than half (n = 678, 59.4%) of patients were classified NYHA Class I; 
      pregnant women in NHYA Class I-II (n = 951, 83.3%) commonly had arrhythmia, 
      myocarditis and its sequelae, while those in NHYA Class III-IV (n = 191, 16.7%) 
      mainly had CHD, rheumatic heart disease (RHD), cardiopathy induced by 
      hypertensive disorders complicating pregnancy, and peripartum cardiomyopathy 
      (PPCM). Cardiac failure occurred in 97 (8.5%) patients, and 8 (0.7%) maternal 
      deaths and 12 (1.1%) perinatal deaths were reported in this study. Compared with 
      those in NHYA Class I-II, women in NHYA Class III-IV had a significantly lower 
      gestational age at birth (P < 0.05), lower birth weight (P < 0.01), and higher 
      incidence of preterm delivery, small for gestational age and perinatal death (P < 
      0.01). The incidence of cardiac failure in pregnant women with cardiopathy 
      induced by hypertensive disorders complicating pregnancy and PPCM was relatively 
      high, with a rate of 80% and 52.2%, respectively. After cardiac operation, 131 
      (90.3%) women were in classified NHYA Class I-II and 14 (9.7%) in NHYA Class 
      III-IV. CONCLUSIONS: Arrhythmia is the type of heart disease that has a highest 
      incidence in patients with heart disease in pregnancy, while main types of heart 
      disease that impair cardiac function are CHD and RHD; cardiac failure is more 
      frequently caused by cardiopathy induced by hypertensive disorders complicating 
      pregnancy and PPCM; impaired cardiac function increases perinatal morbidity; 
      cardiac surgery before pregnancy could improve the cardiac function.
FAU - Liu, Hua
AU  - Liu H
AD  - Department of Obstetrics and Gynecology, Renji Hospital, Affiliated to Shanghai 
      Jiao Tong University School of Medicine, Shanghai Obstetrical Cardiology 
      Intensive Care Center, Shanghai 200127, China.
FAU - Xu, Ji-wen
AU  - Xu JW
FAU - Zhao, Xu-dong
AU  - Zhao XD
FAU - Ye, Tai-yang
AU  - Ye TY
FAU - Lin, Jian-hua
AU  - Lin JH
FAU - Lin, Qi-de
AU  - Lin QD
LA  - eng
PT  - Journal Article
PL  - China
TA  - Chin Med J (Engl)
JT  - Chinese medical journal
JID - 7513795
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Female
MH  - Heart Diseases/complications/*physiopathology/surgery
MH  - Hemodynamics
MH  - Humans
MH  - Pregnancy
MH  - Pregnancy Complications, Cardiovascular/*physiopathology/surgery
MH  - *Pregnancy Outcome
MH  - Retrospective Studies
EDAT- 2010/11/03 06:00
MHDA- 2011/03/09 06:00
CRDT- 2010/11/02 06:00
PHST- 2010/11/02 06:00 [entrez]
PHST- 2010/11/03 06:00 [pubmed]
PHST- 2011/03/09 06:00 [medline]
PST - ppublish
SO  - Chin Med J (Engl). 2010 Sep;123(17):2324-30.