PMID- 21034972
OWN - NLM
STAT- MEDLINE
DCOM- 20110214
LR  - 20101101
IS  - 1557-8445 (Electronic)
IS  - 0065-2776 (Linking)
VI  - 107
DP  - 2010
TI  - Intestinal dendritic cells.
PG  - 109-38
LID - 10.1016/B978-0-12-381300-8.00004-6 [doi]
AB  - Dendritic cells (DCs) are specialized antigen-presenting cells that orchestrate 
      innate and adaptive immune responses. The intestinal mucosa contains numerous DCs 
      that are highly specialized in function. Mucosal DCs display a unique response to 
      toll-like receptor ligands, are capable of driving immunoglobulin isotype 
      switching to IgA, can imprint gut-homing receptors on T and B cells, and drive 
      either T regulatory or Th17 cells depending on the analyzed subtype. These 
      functions are partly cell autonomous and partly conferred by the local 
      microenvironment. In this review, we will summarize the different DC subtypes 
      present in the intestine and in the gut-associated lymphoid tissue (GALT), the 
      unique characteristics of these subtypes, and how the local microenvironment can 
      shape DC function.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Rescigno, Maria
AU  - Rescigno M
AD  - Department of Experimental Oncology, European Institute of Oncology, Milan, 
      Italy.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Adv Immunol
JT  - Advances in immunology
JID - 0370425
SB  - IM
MH  - Animals
MH  - Antigen-Presenting Cells/immunology
MH  - Dendritic Cells/cytology/*immunology
MH  - Humans
MH  - Immunity, Mucosal/*immunology
MH  - Intestinal Mucosa/cytology/*immunology
MH  - Lymphocyte Activation/immunology
EDAT- 2010/11/03 06:00
MHDA- 2011/02/15 06:00
CRDT- 2010/11/02 06:00
PHST- 2010/11/02 06:00 [entrez]
PHST- 2010/11/03 06:00 [pubmed]
PHST- 2011/02/15 06:00 [medline]
AID - B978-0-12-381300-8.00004-6 [pii]
AID - 10.1016/B978-0-12-381300-8.00004-6 [doi]
PST - ppublish
SO  - Adv Immunol. 2010;107:109-38. doi: 10.1016/B978-0-12-381300-8.00004-6.