PMID- 21035385
OWN - NLM
STAT- MEDLINE
DCOM- 20111209
LR  - 20110110
IS  - 1873-5967 (Electronic)
IS  - 1386-6532 (Linking)
VI  - 50
IP  - 1
DP  - 2011 Jan
TI  - Kinetics of cytokine and chemokine responses in patients with primary human 
      herpesvirus 6 infection.
PG  - 65-8
LID - 10.1016/j.jcv.2010.09.017 [doi]
AB  - BACKGROUND: Cytokines and chemokines induced by human herpesvirus 6 (HHV-6) 
      infection may play an important role in the observed HHV-6-associated clinical 
      complications. However, basic data for cytokine and chemokine synthesis in 
      primary HHV-6 infected patient without complication is lacking. OBJECTIVE: Aim of 
      this study was to elucidate basic kinetic data for expressions of cytokines and 
      chemokines in patients with primary HHV-6 infection without complication. STUDY 
      DESIGN: Twenty-six patients suffering from fever were enrolled in this study. 
      Fourteen biomarkers were measured in 74 serially collected sera samples from 26 
      patients. Additionally, serum samples obtained from 14 healthy children were used 
      for control. RESULTS: Twenty of the 26 patients were diagnosed with primary HHV-6 
      infection based on viral isolation and serological analysis. The mean age 
      (P=0.1289) and proportion of males to females (P=0.9999) between the patients 
      with and without primary HHV-6 infection were not statistically different. At the 
      acute phase of the disease, three cytokines (IFN-gamma; P=0.0046, IL-2; P=0.0366, and 
      IL-4; P=0.0255) and one chemokine (MCP-1; P=0.0019) were significantly higher in 
      patients with primary HHV-6 infection compared to those without infection. 
      Interleukin-5 levels during the convalescent period were significantly higher in 
      patients with HHV-6 infection (P=0.0205). By 1 month post-infection, cytokine and 
      chemokine expression had returned to almost basal levels. CONCLUSION: As 
      suggested by the previous in vitro studies, present in vivo analysis also 
      suggests that HHV-6 has potency for induction of cytokines and chemokines.
CI  - Copyright (c) 2010 Elsevier B.V. All rights reserved.
FAU - Yoshikawa, Tetsushi
AU  - Yoshikawa T
AD  - Department of Pediatrics, Fujita Health University School of Medicine, Toyoake, 
      Aichi 4701192, Japan. tetsushi@fujita-hu.ac.jp
FAU - Kato, Yuri
AU  - Kato Y
FAU - Ihira, Masaru
AU  - Ihira M
FAU - Nishimura, Naoko
AU  - Nishimura N
FAU - Ozaki, Takao
AU  - Ozaki T
FAU - Kumagai, Takuji
AU  - Kumagai T
FAU - Asano, Yoshizo
AU  - Asano Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101028
PL  - Netherlands
TA  - J Clin Virol
JT  - Journal of clinical virology : the official publication of the Pan American 
      Society for Clinical Virology
JID - 9815671
RN  - 0 (Antibodies, Viral)
RN  - 0 (Chemokines)
RN  - 0 (Cytokines)
SB  - IM
MH  - Antibodies, Viral/blood
MH  - Chemokines/*blood
MH  - Cytokines/*blood
MH  - Female
MH  - Gene Expression Profiling
MH  - Herpesvirus 6, Human/*immunology/isolation & purification
MH  - Humans
MH  - Infant
MH  - Male
MH  - Roseolovirus Infections/*immunology
EDAT- 2010/11/03 06:00
MHDA- 2011/12/14 06:00
CRDT- 2010/11/02 06:00
PHST- 2010/07/07 00:00 [received]
PHST- 2010/09/18 00:00 [revised]
PHST- 2010/09/23 00:00 [accepted]
PHST- 2010/11/02 06:00 [entrez]
PHST- 2010/11/03 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
AID - S1386-6532(10)00401-4 [pii]
AID - 10.1016/j.jcv.2010.09.017 [doi]
PST - ppublish
SO  - J Clin Virol. 2011 Jan;50(1):65-8. doi: 10.1016/j.jcv.2010.09.017. Epub 2010 Oct 
      28.