PMID- 21035812
OWN - NLM
STAT- MEDLINE
DCOM- 20110203
LR  - 20151119
IS  - 1873-3778 (Electronic)
IS  - 0021-9673 (Linking)
VI  - 1217
IP  - 49
DP  - 2010 Dec 3
TI  - Optimisation of a dispersive liquid-liquid microextraction method for the 
      simultaneous determination of halophenols and haloanisoles in wines.
PG  - 7630-7
LID - 10.1016/j.chroma.2010.10.032 [doi]
AB  - A dispersive liquid-liquid microextraction (DLLME) method has been optimised for 
      simultaneously extracting 2,4,6-trichloranisole (TCA), 2,3,4,6-tetrachloroanisole 
      (TeCA), 2,4,6-tribromoanisole (TBA), pentachloroanisole (PCA), 
      2,4,6-trichlorophenol (TCP), 2,3,4,6-tetrachlorophenol (TeCP), 
      2,4,6-tribromophenol (TBP) and pentachlorophenol (PCP) from wine. The 
      haloanisoles and halophenols were automatically determined using a gas 
      chromatography-electron-capture detection (GC-ECD) system. Derivatisation of 
      halophenols was performed at the same time as DLLME. Firstly, disperser and 
      extraction solvents, salt addition and temperature conditions were selected. 
      Then, the volume of disperser solvent, extraction solvent and derivatisation 
      agent, and the percentage of base were optimised by means of a central composite 
      design combined with desirability functions. The optimal 
      extraction-derivatisation conditions found were 1.3 mL of acetone, 150 muL of 
      carbon tetrachloride, 75 muL of acetic anhydride and a percentage of base of 0.7%; 
      with no salt addition and at room temperature. Under these conditions, the 
      proposed method showed satisfactory linearity (with correlation coefficients over 
      0.994), repeatability (below 9.7%) and reproducibility (below 9.9%). Moreover, 
      detection limits were lower than the olfactory threshold of the compounds. The 
      developed method was successfully applied to the analysis of red wine samples. To 
      our knowledge, this is the first time that DLLME has been applied to determine 
      cork taint responsible compounds in wine.
CI  - Copyright (c) 2010 Elsevier B.V. All rights reserved.
FAU - Pizarro, C
AU  - Pizarro C
AD  - Department of Chemistry, University of La Rioja, C/Madre de Dios 51, 26006 
      Logrono, La Rioja, Spain. consuelo.pizarro@unirioja.es
FAU - Saenz-Gonzalez, C
AU  - Saenz-Gonzalez C
FAU - Perez-del-Notario, N
AU  - Perez-del-Notario N
FAU - Gonzalez-Saiz, J M
AU  - Gonzalez-Saiz JM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101013
PL  - Netherlands
TA  - J Chromatogr A
JT  - Journal of chromatography. A
JID - 9318488
RN  - 0 (Acetic Anhydrides)
RN  - 0 (Anisoles)
RN  - 0 (Chlorophenols)
RN  - 0 (Phenols)
RN  - 1364PS73AF (Acetone)
RN  - 2E48G1QI9Q (acetic anhydride)
RN  - 451W47IQ8X (Sodium Chloride)
RN  - CL2T97X0V0 (Carbon Tetrachloride)
RN  - YS6K3EU393 (2,4,6-tribromophenol)
SB  - IM
MH  - Acetic Anhydrides
MH  - Acetone
MH  - Anisoles/*analysis/chemistry
MH  - Carbon Tetrachloride
MH  - Chemical Fractionation/*methods
MH  - Chlorophenols/*analysis/chemistry
MH  - Chromatography, Gas
MH  - Models, Chemical
MH  - Phenols/*analysis/chemistry
MH  - Reproducibility of Results
MH  - Sodium Chloride
MH  - Temperature
MH  - Wine/*analysis
EDAT- 2010/11/03 06:00
MHDA- 2011/02/04 06:00
CRDT- 2010/11/02 06:00
PHST- 2010/07/27 00:00 [received]
PHST- 2010/10/04 00:00 [revised]
PHST- 2010/10/05 00:00 [accepted]
PHST- 2010/11/02 06:00 [entrez]
PHST- 2010/11/03 06:00 [pubmed]
PHST- 2011/02/04 06:00 [medline]
AID - S0021-9673(10)01395-6 [pii]
AID - 10.1016/j.chroma.2010.10.032 [doi]
PST - ppublish
SO  - J Chromatogr A. 2010 Dec 3;1217(49):7630-7. doi: 10.1016/j.chroma.2010.10.032. 
      Epub 2010 Oct 13.