PMID- 21035858
OWN - NLM
STAT- MEDLINE
DCOM- 20101210
LR  - 20101124
IS  - 1872-9142 (Electronic)
IS  - 0161-5890 (Linking)
VI  - 47
IP  - 16
DP  - 2010 Oct
TI  - Role of interleukin-18 in human natural killer cell is associated with 
      interleukin-2.
PG  - 2604-10
LID - 10.1016/j.molimm.2010.05.290 [doi]
AB  - Human natural killer (NK) cells constitute an important cellular component of 
      innate immunity, capable of killing infected and transformed cells. The 
      proliferation and activation of NK cells are regulated by various cytokines. 
      Interleukin-18 (IL-18) promotes NK cell activation; however, whether the effects 
      of IL-18 on NK cell are associated with other cytokines is still unknown. In this 
      study, we observed that IL-18 induced NK cell apoptosis and inhibited NK cell 
      expansion in the presence of low concentrations of interleukin-2 (IL-2), while 
      high concentrations of IL-2 overcame these effects of IL-18, and high 
      concentrations of IL-2 promoted the stimulatory activity of IL-18 on NK cells. At 
      a low concentration of IL-2, IL-18 induced NK cell apoptosis in part through 
      activation of the FasL/Fas- and TNFalpha/TNFR-mediated death receptor signaling by 
      enhancing FasL expression and inhibiting c-FLIP(long) expression. However, high 
      concentrations of IL-2 strongly blocked IL-18-induced NK cell apoptosis through 
      alleviating IL-18-induced FasL expression and activation of Fas-mediated death 
      signaling and increasing anti-apoptosis molecule (Bcl-X(L)). These results reveal 
      that the effects of IL-18 on human NK cell are associated with IL-2 concentration 
      and suggest the importance of IL-2 level in cytokine immunotherapy.
CI  - Published by Elsevier Ltd.
FAU - Huang, Yong
AU  - Huang Y
AD  - Laboratory of Molecular Virology, Center for Biologics Evaluation and Research, 
      Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20892, USA.
FAU - Lei, YingFeng
AU  - Lei Y
FAU - Zhang, Hai
AU  - Zhang H
FAU - Zhang, Mingjie
AU  - Zhang M
FAU - Dayton, Andrew
AU  - Dayton A
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20101030
PL  - England
TA  - Mol Immunol
JT  - Molecular immunology
JID - 7905289
RN  - 0 (CASP8 and FADD-Like Apoptosis Regulating Protein)
RN  - 0 (CFLAR protein, human)
RN  - 0 (Fas Ligand Protein)
RN  - 0 (IL2 protein, human)
RN  - 0 (Interleukin-18)
RN  - 0 (Interleukin-2)
SB  - IM
MH  - Apoptosis
MH  - CASP8 and FADD-Like Apoptosis Regulating Protein/immunology
MH  - Cells, Cultured
MH  - Fas Ligand Protein/immunology
MH  - Humans
MH  - Interleukin-18/*immunology
MH  - Interleukin-2/*immunology
MH  - Killer Cells, Natural/cytology/*immunology
EDAT- 2010/11/03 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/11/02 06:00
PHST- 2010/04/12 00:00 [received]
PHST- 2010/05/27 00:00 [accepted]
PHST- 2010/11/02 06:00 [entrez]
PHST- 2010/11/03 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - S0161-5890(10)00467-0 [pii]
AID - 10.1016/j.molimm.2010.05.290 [doi]
PST - ppublish
SO  - Mol Immunol. 2010 Oct;47(16):2604-10. doi: 10.1016/j.molimm.2010.05.290. Epub 
      2010 Oct 30.