PMID- 21035918
OWN - NLM
STAT- MEDLINE
DCOM- 20121009
LR  - 20151119
IS  - 1532-818X (Electronic)
IS  - 0196-0709 (Linking)
VI  - 33
IP  - 2
DP  - 2012 Mar-Apr
TI  - Expression of nonclassical molecule human leukocyte antigen-G in oral lesions.
PG  - 193-8
LID - 10.1016/j.amjoto.2010.08.001 [doi]
AB  - INTRODUCTION: Human leukocyte antigen (HLA)-G is a nonclassic class I molecule 
      that acts as a modulator of immune responses, and the expression of these 
      molecules in virus-infected cells has been associated with subversion of the 
      immune response. OBJECTIVE: In this study, we performed a cross-sectional study, 
      systematically comparing the expression of the HLA-G in benign, premalignant, and 
      malignant oral lesions and correlating it with the presence of high-risk and 
      low-risk human papillomavirus (HPV) types. SPECIMENS AND METHODS: Oral biopsies 
      were collected from 51 patients and analyzed by immunohistochemistry using 
      anti-HLA-G antibody. Human papillomavirus detection and typing from oral biopsies 
      were obtained by polymerase chain reaction using GP5+/GP6+ and specific primers. 
      RESULTS: The 51 biopsies were stratified into 3 groups according to lesion grade: 
      oral benign lesions (oral hyperplasia and papilloma, n = 16), oral premalignant 
      lesions (oral leukoplakia with dysplasia and lichen planus, n = 17), and 
      malignant lesions (oral squamous cell carcinoma, n = 18). Human leukocyte 
      antigen-G overexpression was mainly observed in benign and premalignant oral 
      lesions but was not related to HPV infection (P > .05). On the other hand, HPV 
      DNA was detected in 24 (47%) oral lesions, mainly in benign and premalignant 
      lesions, with the most frequent type detected being high-risk HPV type. 
      CONCLUSION: The HLA-G molecule was expressed in a significant number of benign 
      oral lesions and was not correlated with HPV infection or oral cancer.
CI  - Crown Copyright (c) 2012. Published by Elsevier Inc. All rights reserved.
FAU - Fregonezi, Paula A G
AU  - Fregonezi PA
AD  - Department of Clinical Analyses, School of Pharmaceutical Sciences of Araraquara, 
      University of Sao Paulo State, Araraquara, SP, Brazil.
FAU - Silva, Tarsia G A
AU  - Silva TG
FAU - Simoes, Renata T
AU  - Simoes RT
FAU - Moreau, Philipe
AU  - Moreau P
FAU - Carosella, Edgardo D
AU  - Carosella ED
FAU - Klay, Carla P M
AU  - Klay CP
FAU - Goncalves, Maria A G
AU  - Goncalves MA
FAU - Soares, Edson G
AU  - Soares EG
FAU - Souto, Francisco
AU  - Souto F
FAU - Donadi, Eduardo A
AU  - Donadi EA
FAU - Soares, Christiane P
AU  - Soares CP
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101029
PL  - United States
TA  - Am J Otolaryngol
JT  - American journal of otolaryngology
JID - 8000029
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (HLA-G Antigens)
SB  - IM
MH  - Biomarkers, Tumor/biosynthesis/immunology
MH  - Biopsy
MH  - Cross-Sectional Studies
MH  - Follow-Up Studies
MH  - HLA-G Antigens/*biosynthesis/immunology
MH  - Humans
MH  - *Immunity, Cellular
MH  - Immunohistochemistry
MH  - Mouth Mucosa/metabolism/pathology
MH  - Mouth Neoplasms/immunology/*metabolism/pathology
MH  - Retrospective Studies
EDAT- 2010/11/03 06:00
MHDA- 2012/10/10 06:00
CRDT- 2010/11/02 06:00
PHST- 2009/10/27 00:00 [received]
PHST- 2010/08/05 00:00 [revised]
PHST- 2010/08/10 00:00 [accepted]
PHST- 2010/11/02 06:00 [entrez]
PHST- 2010/11/03 06:00 [pubmed]
PHST- 2012/10/10 06:00 [medline]
AID - S0196-0709(10)00147-X [pii]
AID - 10.1016/j.amjoto.2010.08.001 [doi]
PST - ppublish
SO  - Am J Otolaryngol. 2012 Mar-Apr;33(2):193-8. doi: 10.1016/j.amjoto.2010.08.001. 
      Epub 2010 Oct 29.