PMID- 21036197
OWN - NLM
STAT- MEDLINE
DCOM- 20110503
LR  - 20110111
IS  - 1878-4216 (Electronic)
IS  - 0278-5846 (Linking)
VI  - 35
IP  - 1
DP  - 2011 Jan 15
TI  - NTM and NR3C2 polymorphisms influencing intelligence: family-based association 
      studies.
PG  - 154-60
LID - 10.1016/j.pnpbp.2010.10.016 [doi]
AB  - Family, twin, and adoption studies have indicated that human intelligence 
      quotient (IQ) has significant genetic components. We performed a low-density 
      genome-wide association analysis with a family-based association test to identify 
      genetic variants influencing IQ, as measured by Wechsler Adult Intelligence Scale 
      full-score IQ (FSIQ). We examined 11,120 single-nucleotide polymorphisms (SNPs) 
      from the Affymetrix GeneChips 10K mapping array genotyped in 292 nuclear families 
      from Genetic Analysis Workshop 14, a subset from the Collaborative Study on the 
      Genetics of Alcoholism (COGA). A replication analysis was performed using part of 
      International Multi-Center ADHD Genetics Project (IMAGE) dataset. Twenty-two SNPs 
      were identified as having suggestive associations with IQ (p<10(-3)) in the COGA 
      sample and eleven of the SNPs were located within known genes. In particular, NTM 
      at 11q25 (rs411280, p = 0.000764) and NR3C2 at 4q31.1 (rs3846329, p = 0.000675) 
      were two novel genes which have not been associated with IQ in other studies. It 
      has been reported that NTM might play a role in late-onset Alzheimer disease 
      while NR3C2 may be associated with cognitive function and major depression. The 
      associations of these two genes were well-replicated by single-marker and 
      haplotype analyses in the IMAGE sample. In conclusion, our findings provide 
      evidence that chromosome regions of 11q25 and 4q31.1 contain genes affecting IQ. 
      This study will serve as a resource for replication in other populations.
CI  - Published by Elsevier Inc.
FAU - Pan, Yue
AU  - Pan Y
AD  - Department of Mathematics and Statistics, College of Arts and Sciences, East 
      Tennessee State University, Johnson City, TN 37614, USA.
FAU - Wang, Ke-Sheng
AU  - Wang KS
FAU - Aragam, Nagesh
AU  - Aragam N
LA  - eng
GR  - R01 GM31575/GM/NIGMS NIH HHS/United States
GR  - R01MH081803/MH/NIMH NIH HHS/United States
GR  - R01MH62873/MH/NIMH NIH HHS/United States
GR  - U10AA08401/AA/NIAAA NIH HHS/United States
GR  - U10AA08403/AA/NIAAA NIH HHS/United States
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, N.I.H., Extramural
DEP - 20101029
PL  - England
TA  - Prog Neuropsychopharmacol Biol Psychiatry
JT  - Progress in neuro-psychopharmacology & biological psychiatry
JID - 8211617
RN  - 0 (GPI-Linked Proteins)
RN  - 0 (Neural Cell Adhesion Molecules)
RN  - 0 (Receptors, Glucocorticoid)
RN  - 0 (neurotrimin)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Alcoholism/genetics
MH  - Attention Deficit Disorder with Hyperactivity/genetics
MH  - Chromosomes, Human, Pair 11/genetics
MH  - Chromosomes, Human, Pair 4/genetics
MH  - *Family Health
MH  - Female
MH  - GPI-Linked Proteins/genetics
MH  - Genome-Wide Association Study
MH  - Haplotypes
MH  - Humans
MH  - Intelligence/*genetics
MH  - Intelligence Tests
MH  - *International Cooperation
MH  - Male
MH  - Middle Aged
MH  - Neural Cell Adhesion Molecules/*genetics
MH  - *Polymorphism, Single Nucleotide
MH  - Receptors, Glucocorticoid/*genetics
MH  - Young Adult
EDAT- 2010/11/03 06:00
MHDA- 2011/05/04 06:00
CRDT- 2010/11/02 06:00
PHST- 2010/08/04 00:00 [received]
PHST- 2010/10/05 00:00 [revised]
PHST- 2010/10/22 00:00 [accepted]
PHST- 2010/11/02 06:00 [entrez]
PHST- 2010/11/03 06:00 [pubmed]
PHST- 2011/05/04 06:00 [medline]
AID - S0278-5846(10)00389-1 [pii]
AID - 10.1016/j.pnpbp.2010.10.016 [doi]
PST - ppublish
SO  - Prog Neuropsychopharmacol Biol Psychiatry. 2011 Jan 15;35(1):154-60. doi: 
      10.1016/j.pnpbp.2010.10.016. Epub 2010 Oct 29.