PMID- 21036892
OWN - NLM
STAT- MEDLINE
DCOM- 20110217
LR  - 20211020
IS  - 1549-5485 (Electronic)
IS  - 1072-0502 (Print)
IS  - 1072-0502 (Linking)
VI  - 17
IP  - 11
DP  - 2010 Nov
TI  - Differing effects of systemically administered rapamycin on consolidation and 
      reconsolidation of context vs. cued fear memories.
PG  - 577-81
LID - 10.1101/lm.1908310 [doi]
AB  - Rapamycin, an inhibitor of the mammalian target of rapamycin (mTOR) kinase, has 
      attracted interest as a possible prophylactic for post-traumatic stress disorder 
      (PTSD)-associated fear memories. We report here that although rapamycin (40 
      mg/kg, i.p.) disrupted the consolidation and reconsolidation of fear-potentiated 
      startle paradigm to a shock-paired context, it did not disrupt startle increases 
      to a 4-sec odor cue, even though post-training increases in amygdala mTOR 
      activity were prevented by rapamycin (also 40 mg/kg, i.p.). Thus, while rapamycin 
      may prove useful in retarding the development of some PTSD-associated memories, 
      its relative ineffectiveness against cued fear memories may limit its clinical 
      usefulness.
FAU - Glover, Ebony M
AU  - Glover EM
AD  - Department of Psychiatry and Behavioral Sciences, Center for Behavioral 
      Neuroscience, Emory University, Atlanta, Georgia 30302, USA. eglover@emory.edu
FAU - Ressler, Kerry J
AU  - Ressler KJ
FAU - Davis, Michael
AU  - Davis M
LA  - eng
GR  - R01 MH047840/MH/NIMH NIH HHS/United States
GR  - MH 542000/MH/NIMH NIH HHS/United States
GR  - R37 MH047840/MH/NIMH NIH HHS/United States
GR  - MH884697/MH/NIMH NIH HHS/United States
GR  - MH 47840/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20101029
PL  - United States
TA  - Learn Mem
JT  - Learning & memory (Cold Spring Harbor, N.Y.)
JID - 9435678
RN  - 0 (Immunosuppressive Agents)
RN  - EC 2.7.11.1 (Ribosomal Protein S6 Kinases, 70-kDa)
RN  - W36ZG6FT64 (Sirolimus)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Conditioning, Classical/*drug effects
MH  - *Cues
MH  - Electroshock/adverse effects
MH  - Extinction, Psychological/drug effects
MH  - Fear/*drug effects
MH  - Immunosuppressive Agents/administration & dosage/*pharmacology
MH  - Injections, Intraperitoneal/methods
MH  - Male
MH  - Memory/*drug effects
MH  - Odorants
MH  - Phosphorylation/drug effects
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reflex, Startle/drug effects
MH  - Ribosomal Protein S6 Kinases, 70-kDa/metabolism
MH  - Sirolimus/administration & dosage/*pharmacology
MH  - Time Factors
PMC - PMC3256567
EDAT- 2010/11/03 06:00
MHDA- 2011/02/18 06:00
PMCR- 2011/11/01
CRDT- 2010/11/02 06:00
PHST- 2010/11/02 06:00 [entrez]
PHST- 2010/11/03 06:00 [pubmed]
PHST- 2011/02/18 06:00 [medline]
PHST- 2011/11/01 00:00 [pmc-release]
AID - 17/11/577 [pii]
AID - GloverLM19083 [pii]
AID - 10.1101/lm.1908310 [doi]
PST - epublish
SO  - Learn Mem. 2010 Oct 29;17(11):577-81. doi: 10.1101/lm.1908310. Print 2010 Nov.