PMID- 21037522
OWN - NLM
STAT- MEDLINE
DCOM- 20101213
LR  - 20211020
IS  - 1541-8243 (Electronic)
IS  - 0038-4348 (Print)
IS  - 0038-4348 (Linking)
VI  - 103
IP  - 12
DP  - 2010 Dec
TI  - Diverticulitis in a young man with hyper-IgE syndrome.
PG  - 1261-3
LID - 10.1097/SMJ.0b013e3181fa5f0e [doi]
AB  - Autosomal dominant hyperimmunoglobulin E syndrome (HIES, or Job syndrome) is a 
      rare primary immunodeficiency characterized by elevated immunoglobulin E (IgE), 
      eosinophilia, recurrent skin and pulmonary infections, dermatitis, and connective 
      tissue and skeletal abnormalities. A 26-year-old male with known HIES presented 
      with abdominal pain and diarrhea. Imaging showed sigmoid diverticulitis without 
      abscess or perforation. Conservative management with antibiotics failed, and he 
      developed a peridiverticular abscess, which was percutaneously drained with plans 
      for elective resection. He returned four days later with progression of his 
      diverticulitis, requiring partial colectomy with primary anastomosis. To our 
      knowledge, this is the first case of diverticulitis in HIES. Diverticulitis is 
      rare in younger individuals, raising the possibility that the connective tissue 
      abnormalities of HIES patients may predispose them to colonic diverticula. 
      Although the majority of complications are sinopulmonary and skin infections, 
      diverticulitis should be considered in the differential of intra-abdominal 
      processes in HIES.
FAU - Stover, Daniel G
AU  - Stover DG
AD  - Department of Medicine and Laboratory of Clinical Infectious Diseases, National 
      Institute of Allergy and Infectious Diseases, Bethesda, MD, USA.
FAU - Freeman, Alexandra F
AU  - Freeman AF
FAU - Wright, Patty W
AU  - Wright PW
FAU - Hummell, Donna S
AU  - Hummell DS
FAU - Ness, Reid M
AU  - Ness RM
LA  - eng
GR  - P50 CA095103/CA/NCI NIH HHS/United States
GR  - P50 CA095103-090004/CA/NCI NIH HHS/United States
GR  - R01 AT004660/AT/NCCIH NIH HHS/United States
GR  - R01 AT004660-03/AT/NCCIH NIH HHS/United States
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - South Med J
JT  - Southern medical journal
JID - 0404522
SB  - IM
MH  - Adult
MH  - Colectomy
MH  - Diverticulitis, Colonic/diagnosis/*etiology/surgery
MH  - Humans
MH  - Job Syndrome/*complications
MH  - Male
MH  - Tomography, X-Ray Computed
PMC - PMC3059239
MID - NIHMS244256
EDAT- 2010/11/03 06:00
MHDA- 2010/12/14 06:00
PMCR- 2011/12/01
CRDT- 2010/11/02 06:00
PHST- 2010/11/02 06:00 [entrez]
PHST- 2010/11/03 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
PHST- 2011/12/01 00:00 [pmc-release]
AID - 10.1097/SMJ.0b013e3181fa5f0e [doi]
PST - ppublish
SO  - South Med J. 2010 Dec;103(12):1261-3. doi: 10.1097/SMJ.0b013e3181fa5f0e.