PMID- 21037568
OWN - NLM
STAT- MEDLINE
DCOM- 20101230
LR  - 20220129
IS  - 1546-1718 (Electronic)
IS  - 1061-4036 (Print)
IS  - 1061-4036 (Linking)
VI  - 42
IP  - 12
DP  - 2010 Dec
TI  - A genome-wide association study of Hodgkin's lymphoma identifies new 
      susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3).
PG  - 1126-1130
LID - 10.1038/ng.696 [doi]
AB  - To identify susceptibility loci for classical Hodgkin's lymphoma (cHL), we 
      conducted a genome-wide association study of 589 individuals with cHL (cases) and 
      5,199 controls with validation in four independent samples totaling 2,057 cases 
      and 3,416 controls. We identified three new susceptibility loci at 2p16.1 
      (rs1432295, REL, odds ratio (OR) = 1.22, combined P = 1.91 x 10(-8)), 8q24.21 
      (rs2019960, PVT1, OR = 1.33, combined P = 1.26 x 10(-13)) and 10p14 (rs501764, 
      GATA3, OR = 1.25, combined P = 7.05 x 10(-8)). Furthermore, we confirmed the role 
      of the major histocompatibility complex in disease etiology by revealing a strong 
      human leukocyte antigen (HLA) association (rs6903608, OR = 1.70, combined P = 
      2.84 x 10(-50)). These data provide new insight into the pathogenesis of cHL.
FAU - Enciso-Mora, Victor
AU  - Enciso-Mora V
AD  - Section of Cancer Genetics, Institute of Cancer Research, Sutton, SM2 5NG, UK.
FAU - Broderick, Peter
AU  - Broderick P
AD  - Section of Cancer Genetics, Institute of Cancer Research, Sutton, SM2 5NG, UK.
FAU - Ma, Yussanne
AU  - Ma Y
AD  - Section of Cancer Genetics, Institute of Cancer Research, Sutton, SM2 5NG, UK.
FAU - Jarrett, Ruth F
AU  - Jarrett RF
AD  - Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary 
      and Life Sciences, University of Glasgow, Glasgow G61 1QH, UK.
FAU - Hjalgrim, Henrik
AU  - Hjalgrim H
AD  - Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
FAU - Hemminki, Kari
AU  - Hemminki K
AD  - Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), 
      Heidelberg, Germany and Center for Primary Health Care Research, Clinical 
      Research Center, Lund University, Malmo, Sweden.
FAU - van den Berg, Anke
AU  - van den Berg A
AD  - Department of Pathology & Medical Biology, University Medical Centre Groningen, 
      University of Groningen, Groningen, the Netherlands.
FAU - Olver, Bianca
AU  - Olver B
AD  - Section of Cancer Genetics, Institute of Cancer Research, Sutton, SM2 5NG, UK.
FAU - Lloyd, Amy
AU  - Lloyd A
AD  - Section of Cancer Genetics, Institute of Cancer Research, Sutton, SM2 5NG, UK.
FAU - Dobbins, Sara E
AU  - Dobbins SE
AD  - Section of Cancer Genetics, Institute of Cancer Research, Sutton, SM2 5NG, UK.
FAU - Lightfoot, Tracy
AU  - Lightfoot T
AD  - Epidemiology & Genetics Unit, Department of Health Sciences, University of York, 
      York, YO10 5DD, UK.
FAU - van Leeuwen, Flora E
AU  - van Leeuwen FE
AD  - Department of Epidemiology, The Netherlands Cancer Institute - Antoni van 
      Leeuwenhoek Hospital, Amsterdam, the Netherlands.
FAU - Forsti, Asta
AU  - Forsti A
AD  - Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), 
      Heidelberg, Germany and Center for Primary Health Care Research, Clinical 
      Research Center, Lund University, Malmo, Sweden.
FAU - Diepstra, Arjan
AU  - Diepstra A
AD  - Department of Pathology & Medical Biology, University Medical Centre Groningen, 
      University of Groningen, Groningen, the Netherlands.
FAU - Broeks, Annegien
AU  - Broeks A
AD  - Department of Experimental Therapy, The Netherlands Cancer Institute - Antoni van 
      Leeuwenhoek Hospital, Amsterdam, the Netherlands.
FAU - Vijayakrishnan, Jayaram
AU  - Vijayakrishnan J
AD  - Section of Cancer Genetics, Institute of Cancer Research, Sutton, SM2 5NG, UK.
FAU - Shield, Lesley
AU  - Shield L
AD  - Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary 
      and Life Sciences, University of Glasgow, Glasgow G61 1QH, UK.
FAU - Lake, Annette
AU  - Lake A
AD  - Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary 
      and Life Sciences, University of Glasgow, Glasgow G61 1QH, UK.
FAU - Montgomery, Dorothy
AU  - Montgomery D
AD  - Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary 
      and Life Sciences, University of Glasgow, Glasgow G61 1QH, UK.
FAU - Roman, Eve
AU  - Roman E
AD  - Epidemiology & Genetics Unit, Department of Health Sciences, University of York, 
      York, YO10 5DD, UK.
FAU - Engert, Andreas
AU  - Engert A
AD  - University Hospital of Cologne, Department of Internal Medicine, Cologne, 
      Germany.
FAU - von Strandmann, Elke Pogge
AU  - von Strandmann EP
AD  - University Hospital of Cologne, Department of Internal Medicine, Cologne, 
      Germany.
FAU - Reiners, Katrin S
AU  - Reiners KS
AD  - University Hospital of Cologne, Department of Internal Medicine, Cologne, 
      Germany.
FAU - Nolte, Ilja M
AU  - Nolte IM
AD  - Unit of Genetic Epidemiology and Bioinformatics, Department of Epidemiology, 
      University Medical Centre Groningen, University of Groningen, the Netherlands.
FAU - Smedby, Karin E
AU  - Smedby KE
AD  - Unit of Clinical Epidemiology, Department of Medicine, Karolinska University 
      Hospital, SE-171 76, Stockholm, Sweden.
FAU - Adami, Hans-Olov
AU  - Adami HO
AD  - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 
      SE-171 77, Stockholm, Sweden.
AD  - Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, 
      USA.
FAU - Russell, Nicola S
AU  - Russell NS
AD  - Department of Radiotherapy, The Netherlands Cancer Institute - Antoni van 
      Leeuwenhoek Hospital, Amsterdam, the Netherlands.
FAU - Glimelius, Bengt
AU  - Glimelius B
AD  - Department of Pathology and Oncology, Karolinska Institutet, SE-171 77, 
      Stockholm, Sweden.
AD  - Department of Oncology, Radiology and Clinical Immunology, Uppsala University, 
      SE-751 85, Uppsala, Sweden.
FAU - Hamilton-Dutoit, Stephen
AU  - Hamilton-Dutoit S
AD  - Institute of Pathology, Aarhus University Hospital, DK-8000, Aarhus, Denmark.
FAU - de Bruin, Marieke
AU  - de Bruin M
AD  - Department of Epidemiology, The Netherlands Cancer Institute - Antoni van 
      Leeuwenhoek Hospital, Amsterdam, the Netherlands.
FAU - Ryder, Lars P
AU  - Ryder LP
AD  - Department of Clinical Immunology, University Hospital of Copenhagen, 
      Rigshospitalet, DK-2100, Copenhagen, Denmark.
FAU - Molin, Daniel
AU  - Molin D
AD  - Department of Oncology, Radiology and Clinical Immunology, Uppsala University, 
      Uppsala, Sweden.
FAU - Sorensen, Karina Meden
AU  - Sorensen KM
AD  - Department of Clinical Biochemistry, Statens Serum Institut, Copenhagen, Denmark.
FAU - Chang, Ellen T
AU  - Chang ET
AD  - Cancer Prevention Institute of California, Fremont, CA 94538.
AD  - Division of Epidemiology, Department of Health Research and Policy, Stanford 
      University School of Medicine, Stanford, CA 94305, USA.
FAU - Taylor, Malcolm
AU  - Taylor M
AD  - Cancer Immunogenetics Group, School of Cancer & Enabling Sciences, University of 
      Manchester, Research Floor, St Mary's Hospital, Manchester, M13 9WL, UK.
FAU - Cooke, Rosie
AU  - Cooke R
AD  - Section of Epidemiology, Institute of Cancer Research, Sutton, SM2 5NG, UK.
FAU - Hofstra, Robert
AU  - Hofstra R
AD  - Department of Genetics University Medical Centre Groningen, University of 
      Groningen, Groningen, the Netherlands.
FAU - Westers, Helga
AU  - Westers H
AD  - Department of Genetics University Medical Centre Groningen, University of 
      Groningen, Groningen, the Netherlands.
FAU - van Wezel, Tom
AU  - van Wezel T
AD  - Department of Pathology, Leiden University Medical Center, Leiden, the 
      Netherlands.
FAU - van Eijk, Ronald
AU  - van Eijk R
AD  - Department of Pathology, Leiden University Medical Center, Leiden, the 
      Netherlands.
FAU - Ashworth, Alan
AU  - Ashworth A
AD  - The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, 
      Fulham Road, London SW3 6JB, UK.
FAU - Rostgaard, Klaus
AU  - Rostgaard K
AD  - Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
FAU - Melbye, Mads
AU  - Melbye M
AD  - Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
FAU - Swerdlow, Anthony J
AU  - Swerdlow AJ
AD  - Cancer Prevention Institute of California, Fremont, CA 94538.
FAU - Houlston, Richard S
AU  - Houlston RS
AD  - Section of Cancer Genetics, Institute of Cancer Research, Sutton, SM2 5NG, UK.
LA  - eng
GR  - 068545/Z/02/WT_/Wellcome Trust/United Kingdom
GR  - 076113/WT_/Wellcome Trust/United Kingdom
GR  - BREAST CANCER NOW RESEARCH CENTRE/BCN_/Breast Cancer Now/United Kingdom
GR  - G0000934/MRC_/Medical Research Council/United Kingdom
GR  - 085475/WT_/Wellcome Trust/United Kingdom
GR  - A3351/CRUK_/Cancer Research UK/United Kingdom
GR  - C1298/A8362/CRUK_/Cancer Research UK/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101031
PL  - United States
TA  - Nat Genet
JT  - Nature genetics
JID - 9216904
RN  - 0 (GATA3 Transcription Factor)
RN  - 0 (GATA3 protein, human)
RN  - 0 (Proto-Oncogene Proteins c-rel)
SB  - IM
MH  - Adult
MH  - Chromosomes, Human/*genetics
MH  - Chromosomes, Human, Pair 10/genetics
MH  - Chromosomes, Human, Pair 2/genetics
MH  - Chromosomes, Human, Pair 8/genetics
MH  - Female
MH  - GATA3 Transcription Factor/*genetics
MH  - Genetic Loci/*genetics
MH  - *Genetic Predisposition to Disease
MH  - Genome, Human/genetics
MH  - *Genome-Wide Association Study
MH  - Hodgkin Disease/*genetics
MH  - Humans
MH  - Male
MH  - Polymorphism, Single Nucleotide/genetics
MH  - Proto-Oncogene Proteins c-rel/*genetics
MH  - Recombination, Genetic
PMC - PMC4268499
MID - EMS32203
OID - NLM: EMS32203
EDAT- 2010/11/03 06:00
MHDA- 2010/12/31 06:00
PMCR- 2014/12/17
CRDT- 2010/11/02 06:00
PHST- 2010/06/30 00:00 [received]
PHST- 2010/09/30 00:00 [accepted]
PHST- 2010/11/02 06:00 [entrez]
PHST- 2010/11/03 06:00 [pubmed]
PHST- 2010/12/31 06:00 [medline]
PHST- 2014/12/17 00:00 [pmc-release]
AID - 10.1038/ng.696 [doi]
PST - ppublish
SO  - Nat Genet. 2010 Dec;42(12):1126-1130. doi: 10.1038/ng.696. Epub 2010 Oct 31.