PMID- 21038022
OWN - NLM
STAT- MEDLINE
DCOM- 20101207
LR  - 20131121
IS  - 0300-0729 (Print)
IS  - 0300-0729 (Linking)
VI  - 48
IP  - 3
DP  - 2010 Sep
TI  - Sinus aspirates in chronic rhinosinusitis: fungal colonization of paranasal 
      sinuses, evaluation of ICAM-1 and IL-8 and studying of immunological effect of 
      long-term macrolide therapy.
PG  - 312-7
LID - 10.4193/Rhin09.140 [doi]
AB  - PURPOSE: In patients with chronic fungal sinusitis, concentrations of 
      interleukin-8 (IL-8), immunoglobulin E (IgE), and soluble intercellular adhesion 
      molecule-1 (sICAM-1) were compared in paranasal sinus aspirates and serum. 
      Furthermore, immunological effects of macrolide treatment of our patients with 
      chronic fungal rhinosinusitis were also studied. MATERIAL AND METHODS: In our 
      cohort study, 108 patients with chronic rhinosinusitis undergoing sinus surgery 
      were selected. Sinus aspirates were collected, and used for immunological assasy 
      and cultured for fungal study. All patients were examined for the presence of 
      characteristic allergic mucin of chronic allergic fungal rhinosinusitis and this 
      was confirmed later by measurement of total serum IgE. RESULTS: Our cases were 
      classified into 3 groups: chronic rhinosinusitis with positive fungal culture and 
      negative allergic mucin, chronic rhinosinusitis with positive fungal culture and 
      positive allergic mucin and chronic rhinosinusitis without fungal growth. A 
      control group was included. We found 57.4% of the patient cultures positive for 
      fungus and 36.4% of the control subjects. Aspergillus ssp. were the most 
      prevalent followed by Bipolaris ssp., and Curvularia. IgE levels were increased 
      in group II compared to group I, III and IV. ICAM-1 and IL-8 levels were 
      increased in groups I, II and III compared to the control group. Erythromycin 
      given in group II decreased the levels of IL-8 and ICAM-1. CONCLUSION: 
      Aspergillus species were the most common. These results confirm the role of 
      ICAM-1 and IL-8 in all types of rhinosinusitis. Erythromycin modulated the immune 
      status of the patients.
FAU - Elmorsy, Shawky
AU  - Elmorsy S
AD  - Otorhinolaryngology Department, Mansoura University, Mansoura, Egypt. 
      Shawky_morsy2003@yahoo.com
FAU - El-Naggar, Mohammed M
AU  - El-Naggar MM
FAU - Abdel aal, Sanaa M
AU  - Abdel aal SM
FAU - Abou-elela, Mohammad A
AU  - Abou-elela MA
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Rhinology
JT  - Rhinology
JID - 0347242
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Interleukin-8)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 63937KV33D (Erythromycin)
SB  - IM
MH  - Adult
MH  - Anti-Bacterial Agents/administration & dosage
MH  - Chronic Disease
MH  - Erythromycin/administration & dosage
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/analysis
MH  - Intercellular Adhesion Molecule-1/*analysis/blood
MH  - Interleukin-8/*analysis/blood
MH  - Male
MH  - Paranasal Sinuses/*microbiology
MH  - Rhinitis/*microbiology
MH  - Sinusitis/*microbiology
EDAT- 2010/11/03 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/11/02 06:00
PHST- 2010/11/02 06:00 [entrez]
PHST- 2010/11/03 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 09.140 [pii]
AID - 10.4193/Rhin09.140 [doi]
PST - ppublish
SO  - Rhinology. 2010 Sep;48(3):312-7. doi: 10.4193/Rhin09.140.