PMID- 21038378
OWN - NLM
STAT- MEDLINE
DCOM- 20110103
LR  - 20220318
IS  - 1097-4598 (Electronic)
IS  - 0148-639X (Linking)
VI  - 42
IP  - 6
DP  - 2010 Dec
TI  - The 6-minute walk test in Duchenne/Becker muscular dystrophy: longitudinal 
      observations.
PG  - 966-74
LID - 10.1002/mus.21808 [doi]
AB  - In this study we used the 6-minute walk distance (6MWD) to characterize 
      ambulation over time in Duchenne/Becker muscular dystrophy (DBMD). The 6MWD was 
      assessed in 18 boys with DBMD and 22 healthy boys, ages 4-12 years, over mean 
      [range] intervals of 58 [39-87] and 69 [52-113] weeks, respectively. Height and 
      weight increased similarly in both groups. At 52 weeks, 6MWD decreased in 12 of 
      18 (67%) DBMD subjects (overall mean [range]: 357 [125-481] to 300 [0-510] 
      meters; Delta -57 meters, -15.9%), but increased in 14 of 22 (64%) healthy subjects 
      (overall mean [range]: 623 [479-754] to 636 [547-717] meters; Delta +13 meters, 
      +2.1%). Two DBMD subjects lost ambulation. Changes in 6MWD depended on stride 
      length and age; improvements usually occurred by 7-8 years of age; older DBMD 
      subjects worsened, whereas older healthy subjects were stable. The 6MWD changes 
      at 1 year confirm the validity of this endpoint and emphasize that preserving 
      ambulation must remain a major goal of DBMD therapy.
FAU - McDonald, Craig M
AU  - McDonald CM
AD  - Department of Physical Medicine and Rehabilitation, University of California 
      Davis School of Medicine, Sacramento, California 95817, USA. 
      cmmcdonald@ucdavis.edu
FAU - Henricson, Erik K
AU  - Henricson EK
FAU - Han, Jay J
AU  - Han JJ
FAU - Abresch, R Ted
AU  - Abresch RT
FAU - Nicorici, Alina
AU  - Nicorici A
FAU - Atkinson, Leone
AU  - Atkinson L
FAU - Elfring, Gary L
AU  - Elfring GL
FAU - Reha, Allen
AU  - Reha A
FAU - Miller, Langdon L
AU  - Miller LL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Muscle Nerve
JT  - Muscle & nerve
JID - 7803146
SB  - IM
MH  - Body Height
MH  - Body Weight
MH  - Child
MH  - Child, Preschool
MH  - Disease Progression
MH  - Follow-Up Studies
MH  - Gait/*physiology
MH  - Humans
MH  - Male
MH  - Muscular Dystrophy, Duchenne/*physiopathology
MH  - Walking/*physiology
EDAT- 2010/11/03 06:00
MHDA- 2011/01/05 06:00
CRDT- 2010/11/02 06:00
PHST- 2010/11/02 06:00 [entrez]
PHST- 2010/11/03 06:00 [pubmed]
PHST- 2011/01/05 06:00 [medline]
AID - 10.1002/mus.21808 [doi]
PST - ppublish
SO  - Muscle Nerve. 2010 Dec;42(6):966-74. doi: 10.1002/mus.21808.