PMID- 21038668
OWN - NLM
STAT- MEDLINE
DCOM- 20120604
LR  - 20101101
IS  - 1000-6834 (Print)
IS  - 1000-6834 (Linking)
VI  - 26
IP  - 3
DP  - 2010 Aug
TI  - [Apoptosis in myocyte after repeated + Gz exposures in rats].
PG  - 275-7
AB  - OBJECTIVE: To observe the effects of repeated + Gz exposures on the apoptosis of 
      myocyte in rats. METHODS: Twelve male Sprague-Dawley rats were randomly divided 
      into three groups: Control group, + 6Gz group and + 10Gz group. The rats of + Gz 
      groups were exposed to + 6Gz for 3 min, + 10Gz for 3 min respectively, 1 b/d, 1 
      week. Four control rats were kept at the Earth gravity (1G) in the room with the 
      centrifuge. All animals were anaesthetized and anatomies 1 day after the last 
      exposure. Ventricular myocardium was studied by electron microscopy and terminal 
      deoxynucleotide transferase-mediated dUTP nick end labeling (TUNEL) method. 
      RESULTS: The apoptosis of myocyte in control group and + 6Gz group were scarcely 
      observed by electron microscopy, while heterochromatin concentration and 
      margination were observed in + 10Gz group. The apoptotic index of myocardium 
      increased significantly in + 6Gz and + 10Gz group compared with that of the 
      control group (P < 0.05) and showed the largest value in the + 10Gz group (P < 
      0.05). CONCLUSION: Repeated + Gz exposures may induce apoptosis in myocyte, and 
      the number of apoptosis in myocyte increases gradually with the increase of G 
      value.
FAU - Zhou, Ying
AU  - Zhou Y
AD  - The Faculty of Aerospace Medicine, Fourth Military Medical University, Xi'an 
      710033, China.
FAU - Wang, Bing
AU  - Wang B
FAU - Wang, Yong-Chun
AU  - Wang YC
FAU - Wu, Yan-Hong
AU  - Wu YH
FAU - Zhang, Shu
AU  - Zhang S
FAU - Geng, Jie
AU  - Geng J
FAU - Sun, Xi-Qing
AU  - Sun XQ
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhongguo Ying Yong Sheng Li Xue Za Zhi
JT  - Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = 
      Chinese journal of applied physiology
JID - 9426407
SB  - IM
MH  - *Acceleration
MH  - Animals
MH  - Apoptosis/*physiology
MH  - Male
MH  - Myocardium/*cytology
MH  - Myocytes, Cardiac/*physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 2010/11/03 06:00
MHDA- 2012/06/05 06:00
CRDT- 2010/11/03 06:00
PHST- 2010/11/03 06:00 [entrez]
PHST- 2010/11/03 06:00 [pubmed]
PHST- 2012/06/05 06:00 [medline]
PST - ppublish
SO  - Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2010 Aug;26(3):275-7.