PMID- 21038694
OWN - NLM
STAT- MEDLINE
DCOM- 20120604
LR  - 20131121
IS  - 1000-6834 (Print)
IS  - 1000-6834 (Linking)
VI  - 26
IP  - 3
DP  - 2010 Aug
TI  - [Effect of progesterone on MMP-3 expression in neonatal rat brain after 
      hypoxic-ischemia].
PG  - 370-3
AB  - OBJECTIVE: To study the effect of progesterone on matrix metalloproteinase-3 
      (MMP-3) expression in neonatal rat brain after hypoxic-ischemia. METHODS: 
      Followed the hypoxic-ischemia of neonatal rat brain, Evans blue (EB) staining and 
      transmission electron microscopy were used to detect the blood-brain barrier 
      pathological changes on permeability. MMP-3 protein expression in cerebral cortex 
      was measured with Western blot. RESULTS: Transmission electron microscopy results 
      showed that the blood brain barrier in hypoxic-ischemic group changed 
      significantly compare to progesterone group. EB staining results suggested that 
      the blood-brain barrier permeability of hypoxic-ischemic group was significantly 
      increased compared to sham-operated group (P < 0.01). The blood-brain barrier 
      permeability in progesterone group was also decreased in comparison to that of 
      hypoxic-ischemic group (P < 0.05). Western blot image analysis results indicated 
      that MMP-3 protein expression in the hypoxic-ischemic group increased 
      significantly than that in sham-operated group (P < 0.01), and the progesterone 
      group was decreased significantly than that in hypoxic-ischemic group (P < 0.05). 
      CONCLUSION: Progesterone may reduce the blood-brain barrier damage by reducing 
      MMP-3 expression. This might be one of the protective mechanisms in the 
      hypoxic-ischemic brain injury.
FAU - Xu, Chun-Yang
AU  - Xu CY
AD  - Department of Physiology, Xinxiang Medical College, Xinxiang 453003, China.
FAU - Li, Shuang
AU  - Li S
FAU - Li, Xin-Qiang
AU  - Li XQ
FAU - Li, Dong-Liang
AU  - Li DL
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhongguo Ying Yong Sheng Li Xue Za Zhi
JT  - Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = 
      Chinese journal of applied physiology
JID - 9426407
RN  - 4G7DS2Q64Y (Progesterone)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Blood-Brain Barrier/*physiopathology
MH  - Hypoxia-Ischemia, Brain/*metabolism/pathology/physiopathology
MH  - Matrix Metalloproteinase 3/*metabolism
MH  - Progesterone/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 2010/11/03 06:00
MHDA- 2012/06/05 06:00
CRDT- 2010/11/03 06:00
PHST- 2010/11/03 06:00 [entrez]
PHST- 2010/11/03 06:00 [pubmed]
PHST- 2012/06/05 06:00 [medline]
PST - ppublish
SO  - Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2010 Aug;26(3):370-3.