PMID- 21038791
OWN - NLM
STAT- MEDLINE
DCOM- 20110209
LR  - 20161125
IS  - 0125-877X (Print)
IS  - 0125-877X (Linking)
VI  - 28
IP  - 2-3
DP  - 2010 Jun-Sep
TI  - A combination of intravenous immunoglobulin and pulse methylprednisolone extended 
      survival in pulmonary alveolar proteinosis with chronic interstitial pneumonitis: 
      a case report.
PG  - 200-5
AB  - Pulmonary alveolar proteinosis (PAP) is characterized by intra-alveolar 
      accumulation of lipoproteinaceous material. The severe chronic pulmonary disease 
      and susceptibility to pulmonary infection is a prominent feature of the disease. 
      We reported a case of postnatal-onset PAP and chronic interstitial pneumonitis in 
      a girl with chronic respiratory distress since she was 5 months of age. A lung 
      biopsy confirmed the diagnosis. The therapeutic bronchoalveolar lavages, a short 
      trial of granulocyte colony-stimulation factor (G-CSF) and a combination of low 
      dose methylprednisolone and hydroxychloroquine were used at different times 
      without noting satisfactory improvement. Intravenous immunoglobulin (IVIG) and 
      pulse methylprednisolone were given monthly with gradual recovery. She did not 
      require oxygen supplement after 21 months of this combination. Our report 
      suggested that IVIG and pulse methylprednisolone might have a potential role in 
      the treatment of PAP with chronic interstitial pneumonitis.
FAU - Jirarattanasopa, Nongnapa
AU  - Jirarattanasopa N
AD  - Division of Allergy and Immunology, Department of Pediatrics, Faculty of Medicine 
      Siriraj Hospital Mahidol University, Bangkok, Thailand.
FAU - Tantikul, Chutsumarn
AU  - Tantikul C
FAU - Vichyanond, Pakit
AU  - Vichyanond P
FAU - Pacharn, Punchama
AU  - Pacharn P
FAU - Visitsunthorn, Nualanong
AU  - Visitsunthorn N
FAU - Suttinont, Panthep
AU  - Suttinont P
FAU - Jirapongsananuruk, Orathai
AU  - Jirapongsananuruk O
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Thailand
TA  - Asian Pac J Allergy Immunol
JT  - Asian Pacific journal of allergy and immunology
JID - 8402034
RN  - 0 (Immunoglobulins, Intravenous)
RN  - X4W7ZR7023 (Methylprednisolone)
SB  - IM
MH  - Chronic Disease
MH  - Cyanosis
MH  - Dyspnea
MH  - Fatal Outcome
MH  - Female
MH  - Humans
MH  - Hyperbaric Oxygenation
MH  - Immunoglobulins, Intravenous/administration & dosage
MH  - Infant
MH  - Infant, Newborn
MH  - Lung/immunology/*metabolism/microbiology/pathology
MH  - Lung Diseases, Interstitial/complications/*diagnosis/physiopathology/therapy
MH  - Methylprednisolone/administration & dosage
MH  - Pneumocystis carinii/*immunology/pathogenicity
MH  - Pulmonary Alveolar Proteinosis/complications/*diagnosis/physiopathology/therapy
MH  - Respiratory Insufficiency
EDAT- 2010/11/03 06:00
MHDA- 2011/02/10 06:00
CRDT- 2010/11/03 06:00
PHST- 2010/11/03 06:00 [entrez]
PHST- 2010/11/03 06:00 [pubmed]
PHST- 2011/02/10 06:00 [medline]
PST - ppublish
SO  - Asian Pac J Allergy Immunol. 2010 Jun-Sep;28(2-3):200-5.