PMID- 21039324
OWN - NLM
STAT- MEDLINE
DCOM- 20111227
LR  - 20131121
IS  - 1473-0790 (Electronic)
IS  - 1368-5538 (Linking)
VI  - 14
IP  - 3
DP  - 2011 Sep
TI  - Low total testosterone is associated with increased risk of incident type 2 
      diabetes mellitus in men: results from the Study of Health in Pomerania (SHIP).
PG  - 168-75
LID - 10.3109/13685538.2010.524955 [doi]
AB  - OBJECTIVE: There is increasing evidence suggesting that low total testosterone 
      concentration is associated with incident type 2 diabetes mellitus (T2DM) in men. 
      The aim of this study was to evaluate the association between total testosterone 
      and incident T2DM in a large population-based cohort. METHODS: Of 2117 men at 
      baseline, 1589 were followed up 5 years later. Low total testosterone 
      concentration at baseline determined by <10th percentile (10-year age-strata) 
      were used as a risk factor for incident T2DM at follow-up. To evaluate for 
      potential non-response bias, drop out weights were used in sensitivity analysis. 
      RESULTS: From 1339 men eligible for analyses, 68 (5.1%) developed T2DM. Men with 
      low total testosterone concentration had an increased risk of developing T2DM 
      (odds ratio [OR] 3.4, 95% CI 1.9-6.1), even after adjustment for age, waist 
      circumference and smoking, OR 3.0; (95% CI 1.6-5.7). Recalculated weighted models 
      revealed almost identical estimates indicating no relevant non-response bias. 
      DISCUSSION: Our prospective findings suggest that low total testosterone 
      concentration is associated with incident T2DM in men and might represent a 
      biomarker that might causally be involved in the risk of T2DM. This underlines 
      the importance of measuring total testosterone in men as the predominant male sex 
      hormone.
FAU - Schipf, Sabine
AU  - Schipf S
AD  - Institute of Clinical Chemistry and Laboratory Medicine, Ernst Moritz 
      Arndt-University Greifswald, Germany. sabine.schipf@uni-greifswald.de
FAU - Haring, Robin
AU  - Haring R
FAU - Friedrich, Nele
AU  - Friedrich N
FAU - Nauck, Matthias
AU  - Nauck M
FAU - Lau, Katharina
AU  - Lau K
FAU - Alte, Dietrich
AU  - Alte D
FAU - Stang, Andreas
AU  - Stang A
FAU - Volzke, Henry
AU  - Volzke H
FAU - Wallaschofski, Henri
AU  - Wallaschofski H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101102
PL  - England
TA  - Aging Male
JT  - The aging male : the official journal of the International Society for the Study 
      of the Aging Male
JID - 9808210
RN  - 0 (Blood Glucose)
RN  - 0 (Cholesterol, HDL)
RN  - 0 (Cholesterol, LDL)
RN  - 3XMK78S47O (Testosterone)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Blood Glucose/analysis
MH  - Body Mass Index
MH  - Cholesterol, HDL/blood
MH  - Cholesterol, LDL/blood
MH  - *Diabetes Mellitus, Type 2/epidemiology/metabolism
MH  - Follow-Up Studies
MH  - Germany/epidemiology
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - Motor Activity
MH  - Odds Ratio
MH  - Risk Factors
MH  - *Testosterone/analysis/blood
MH  - Waist Circumference
EDAT- 2010/11/03 06:00
MHDA- 2011/12/28 06:00
CRDT- 2010/11/03 06:00
PHST- 2010/11/03 06:00 [entrez]
PHST- 2010/11/03 06:00 [pubmed]
PHST- 2011/12/28 06:00 [medline]
AID - 10.3109/13685538.2010.524955 [doi]
PST - ppublish
SO  - Aging Male. 2011 Sep;14(3):168-75. doi: 10.3109/13685538.2010.524955. Epub 2010 
      Nov 2.