PMID- 21039365
OWN - NLM
STAT- MEDLINE
DCOM- 20111019
LR  - 20151119
IS  - 1600-0404 (Electronic)
IS  - 0001-6314 (Linking)
VI  - 124
IP  - 1
DP  - 2011 Jul
TI  - Non-interventional surveillance study of adverse events in patients with 
      epilepsy.
PG  - 13-21
LID - 10.1111/j.1600-0404.2010.01440.x [doi]
AB  - OBJECTIVES: Compare adverse events (AEs) in patients with epilepsy taking 
      different antiepileptic drugs (AEDs) using standardized physician-completed 
      questionnaires. MATERIALS AND METHODS: Multicenter, observational, 
      cross-sectional study in epilepsy patients aged >/=4 , stable on 1-2 AED(s) for >/=3 
      months. RESULTS: One thousand and nineteen patients were evaluated: 28.7% took 
      newer, 71.3% older (or older + newer) AED(s); 56.9% monotherapy; 43.1% 
      polytherapy. Overall, 68.3% reported >/=1 AE (61.3% newer; 71.1% older AEDs), most 
      commonly: cognitive function disturbances, sedation, psychological problems. 
      Patients taking newer AEDs were significantly less likely to report >/=1 AE (OR 
      [95% CI]: 0.64 [0.46-0.89], P = 0.008). Treatment/dose changed at study visit: 
      22.8% (17.5% newer; 24.9% older AEDs) because of (newer/older); lack of efficacy 
      (6.2%/7.8%); AEs (4.1/8.4%); absence of seizures (3.8/4.0%). Patients receiving 
      levetiracetam or lamotrigine were significantly less likely to report AEs/modify 
      treatment. CONCLUSION: Patients taking newer AEDs were significantly less likely 
      to report AEs, although the non-randomized study design does not allow the lower 
      rate of AEs to be attributed with certainty to the use of newer AEDs. A 
      standardized AE questionnaire appeared useful for monitoring AEs/optimizing AED 
      therapy.
CI  - (c) 2010 John Wiley & Sons A/S.
FAU - Cramer, J A
AU  - Cramer JA
AD  - Yale University, Epilepsy Therapy Project, Houston, TX 77027-9310, USA. 
      joyce.cramer@yale.edu
FAU - Steinborn, B
AU  - Steinborn B
FAU - Striano, P
AU  - Striano P
FAU - Hlinkova, L
AU  - Hlinkova L
FAU - Bergmann, A
AU  - Bergmann A
FAU - Bacos, I
AU  - Bacos I
FAU - Baukens, C
AU  - Baukens C
FAU - Buyle, S
AU  - Buyle S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101012
PL  - Denmark
TA  - Acta Neurol Scand
JT  - Acta neurologica Scandinavica
JID - 0370336
RN  - 0 (Anticonvulsants)
SB  - IM
MH  - Adult
MH  - Anticonvulsants/*adverse effects/therapeutic use
MH  - Cross-Sectional Studies
MH  - Drug Therapy, Combination
MH  - Epilepsy/*drug therapy
MH  - Europe
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Surveys and Questionnaires
EDAT- 2010/11/03 06:00
MHDA- 2011/10/20 06:00
CRDT- 2010/11/03 06:00
PHST- 2010/11/03 06:00 [entrez]
PHST- 2010/11/03 06:00 [pubmed]
PHST- 2011/10/20 06:00 [medline]
AID - 10.1111/j.1600-0404.2010.01440.x [doi]
PST - ppublish
SO  - Acta Neurol Scand. 2011 Jul;124(1):13-21. doi: 10.1111/j.1600-0404.2010.01440.x. 
      Epub 2010 Oct 12.