PMID- 21041032
OWN - NLM
STAT- MEDLINE
DCOM- 20110523
LR  - 20110111
IS  - 1532-2777 (Electronic)
IS  - 0306-9877 (Linking)
VI  - 76
IP  - 2
DP  - 2011 Feb
TI  - Can IgE-mediated allergic diseases be prevented by using allergen-specific IgG 
      antibodies?
PG  - 271-3
LID - 10.1016/j.mehy.2010.10.020 [doi]
AB  - The prevalence of allergic disease has increased significantly over the past few 
      decades, especially in children. Prenatal period may represent an ideal time for 
      the implementation of interventions to prevent allergy and allergic diseases. In 
      this hypothesis, allergen-specific immunoglobulin G (IgG) antibodies may combine 
      with maternal allergens as blocking antibodies with immunoglobulin E (IgE) or 
      mask antigenic determinants in their binding to prevent the sensitization of the 
      fetus. It may also modify fetal immune response to prevent the production of 
      allergen-specific IgE antibodies and the further development of allergic 
      diseases. Recent epidemiological, immunological and intervention studies 
      supporting the hypothesis were summarized. Anti-mite human IgG Fabs (antigen 
      binding fragments) were prepared from two immunoglobulin genes libraries and they 
      were confirmed to have a specific binding blocking property by an in vitro 
      mastocyte degranulation inhibition test. Allergen-specific human IgG antibodies 
      may have a potential use in the prenatal immunoprophylaxis or the prevention of 
      allergic diseases after birth.
CI  - Copyright A(c) 2010 Elsevier Ltd. All rights reserved.
FAU - Shao, Hongxia
AU  - Shao H
AD  - Department of Medical Microbiology and Parasitology, Shanghai Medical College of 
      Fudan University, China.
FAU - Tachibana, Hiroshi
AU  - Tachibana H
FAU - Cheng, Xunjia
AU  - Cheng X
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101030
PL  - United States
TA  - Med Hypotheses
JT  - Medical hypotheses
JID - 7505668
RN  - 0 (Immunoglobulin Fab Fragments)
RN  - 0 (Immunoglobulin G)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Animals
MH  - Female
MH  - Humans
MH  - Hypersensitivity/*immunology/*prevention & control
MH  - Immune System
MH  - Immunoglobulin E/*chemistry/immunology
MH  - Immunoglobulin Fab Fragments/chemistry
MH  - Immunoglobulin G/*chemistry/immunology
MH  - Infant, Newborn
MH  - Male
MH  - Mast Cells/cytology
MH  - Mites
MH  - Models, Theoretical
MH  - Pregnancy
EDAT- 2010/11/03 06:00
MHDA- 2011/05/24 06:00
CRDT- 2010/11/03 06:00
PHST- 2010/05/23 00:00 [received]
PHST- 2010/10/12 00:00 [accepted]
PHST- 2010/11/03 06:00 [entrez]
PHST- 2010/11/03 06:00 [pubmed]
PHST- 2011/05/24 06:00 [medline]
AID - S0306-9877(10)00431-7 [pii]
AID - 10.1016/j.mehy.2010.10.020 [doi]
PST - ppublish
SO  - Med Hypotheses. 2011 Feb;76(2):271-3. doi: 10.1016/j.mehy.2010.10.020. Epub 2010 
      Oct 30.