PMID- 21042708
OWN - NLM
STAT- MEDLINE
DCOM- 20110224
LR  - 20190606
IS  - 1791-2423 (Electronic)
IS  - 1019-6439 (Linking)
VI  - 37
IP  - 6
DP  - 2010 Dec
TI  - Identification and characterization of early growth response 2, a zinc-finger 
      transcription factor, as a p53-regulated proapoptotic gene.
PG  - 1407-16
AB  - Tumor suppressor p53 is a transcription factor that induces growth arrest and/or 
      apoptosis in response to cellular stress. In recent years, many genes have been 
      identified as p53-regulated genes; however, no single target gene has been shown 
      to be required for the apoptotic effect. Using microarray analysis, we have 
      identified the transcription factor early growth response 2 (EGR2) as a target of 
      the p53 family, specifically p53, p63 and p73. EGR2 expression was up-regulated 
      by DNA damage-induced p53 activity, as well as by overexpression of p53 family 
      genes. Furthermore, we identified a responsive element to p53, TAp63, and TAp73 
      within the EGR2 gene. This response element is highly conserved between human and 
      rodents. We also found that overexpression of EGR2 induced apoptosis when 
      combined with anticancer agents. Conversely, inactivation of EGR2 attenuated 
      p53-mediated apoptosis. The results presented here suggest that EGR2 is a direct 
      transcriptional target of p53 family that can in part mediate the p53-dependent 
      apoptotic pathway.
FAU - Yokota, Ikuko
AU  - Yokota I
AD  - Department of Molecular Biology, Cancer Research Institute, Sapporo Medical 
      University School of Medicine, Chuo-ku, Sapporo 060-8556, Japan.
FAU - Sasaki, Yasushi
AU  - Sasaki Y
FAU - Kashima, Lisa
AU  - Kashima L
FAU - Idogawa, Masashi
AU  - Idogawa M
FAU - Tokino, Takashi
AU  - Tokino T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Greece
TA  - Int J Oncol
JT  - International journal of oncology
JID - 9306042
RN  - 0 (Early Growth Response Protein 2)
RN  - 0 (RNA, Small Interfering)
RN  - 0 (Transcription Factors)
RN  - 0 (Tumor Suppressor Protein p53)
SB  - IM
MH  - Animals
MH  - Apoptosis/drug effects/*genetics
MH  - Base Sequence
MH  - Cells, Cultured
MH  - Early Growth Response Protein 2/antagonists & inhibitors/*genetics/metabolism
MH  - *Gene Expression Regulation/drug effects
MH  - HCT116 Cells
MH  - HeLa Cells
MH  - Humans
MH  - Mice
MH  - Mice, Knockout
MH  - Molecular Sequence Data
MH  - RNA, Small Interfering/pharmacology
MH  - Rats
MH  - Sequence Homology, Nucleic Acid
MH  - Transcription Factors/antagonists & inhibitors/genetics/metabolism
MH  - Tumor Suppressor Protein p53/*physiology
MH  - Zinc Fingers/genetics
EDAT- 2010/11/03 06:00
MHDA- 2011/02/25 06:00
CRDT- 2010/11/03 06:00
PHST- 2010/11/03 06:00 [entrez]
PHST- 2010/11/03 06:00 [pubmed]
PHST- 2011/02/25 06:00 [medline]
AID - 10.3892/ijo_00000792 [doi]
PST - ppublish
SO  - Int J Oncol. 2010 Dec;37(6):1407-16. doi: 10.3892/ijo_00000792.