PMID- 21044079
OWN - NLM
STAT- MEDLINE
DCOM- 20130820
LR  - 20101207
IS  - 1471-4159 (Electronic)
IS  - 0022-3042 (Linking)
VI  - 116
IP  - 1
DP  - 2011 Jan
TI  - Role of matrix metalloproteinase-3 in neurodegeneration.
PG  - 22-32
LID - 10.1111/j.1471-4159.2010.07082.x [doi]
AB  - Matrix metalloproteinase-3 (MMP-3) is a member of the class of zinc-dependent 
      proteases known to degrade the extracellular matrix. MMP-3 activity is regulated 
      at three different levels: gene expression, proteolytic activation of the 
      zymogen, and inhibition by the endogenous tissue inhibitors of metalloproteinase. 
      A line of evidence indicates a role of MMP-3 in neurodegeneration. In neuronal 
      cells, MMP-3 expression is increased in response to cell stress, and the cleaved, 
      active MMP-3 participates in apoptotic signaling. In the extracellular space, 
      MMP-3 triggers microglia to produce proinflammatory and cytotoxic molecules as 
      well as MMP-3, which in turn contribute to neuronal damage. MMP-3 is increased in 
      various experimental models of Parkinson's disease that are produced by selective 
      toxins and by inflammagen, and the neuronal death is attenuated by various ways 
      that inhibit MMP-3. alpha-Synuclein, whose gene mutations are associated with 
      familial forms of Parkinson's disease, is proteolyzed by MMP-3. Contribution of 
      MMP-3 toward the pathogenesis of Alzheimer's disease and other neurodegenerative 
      diseases has also been suggested. Thus, modulation of MMP-3 expression and/or 
      activity could be of therapeutic value for neurodegenerative diseases.
FAU - Kim, Eun-Mee
AU  - Kim EM
AD  - Department of Biochemistry and Molecular Biology, University of Ulsan College of 
      Medicine, Seoul, Korea.
FAU - Hwang, Onyou
AU  - Hwang O
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20101202
PL  - England
TA  - J Neurochem
JT  - Journal of neurochemistry
JID - 2985190R
RN  - 0 (Matrix Metalloproteinase Inhibitors)
RN  - 0 (Protease Inhibitors)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Animals
MH  - Apoptosis/drug effects/physiology
MH  - Humans
MH  - Matrix Metalloproteinase 3/metabolism/*physiology
MH  - *Matrix Metalloproteinase Inhibitors
MH  - Nerve Degeneration/drug therapy/*enzymology/pathology
MH  - Protease Inhibitors/pharmacology/therapeutic use
EDAT- 2010/11/04 06:00
MHDA- 2013/08/21 06:00
CRDT- 2010/11/04 06:00
PHST- 2010/11/04 06:00 [entrez]
PHST- 2010/11/04 06:00 [pubmed]
PHST- 2013/08/21 06:00 [medline]
AID - 10.1111/j.1471-4159.2010.07082.x [doi]
PST - ppublish
SO  - J Neurochem. 2011 Jan;116(1):22-32. doi: 10.1111/j.1471-4159.2010.07082.x. Epub 
      2010 Dec 2.