PMID- 21045428
OWN - NLM
STAT- MEDLINE
DCOM- 20110203
LR  - 20161125
IS  - 0974-5130 (Electronic)
IS  - 0377-4929 (Linking)
VI  - 53
IP  - 4
DP  - 2010 Oct-Dec
TI  - Cryptic PML-RARalpha positive acute promyelocytic leukemia with unusual morphology 
      and cytogenetics.
PG  - 817-9
LID - 10.4103/0377-4929.72097 [doi]
AB  - Acute Promyelocytic Leukemia (APL) is different from other forms of acute myeloid 
      leukemia (AML), to the reason being the potential devastating coagulopathy and 
      the sensitivity to all-trans retinoic acid (ATRA) and arsenic trioxide (As 2 O 3 
      ). We hereby present a case of APL, morphologically distinct from the 
      hypergranular APL; however, the flow cytometry revealed a characteristic 
      phenotype showing dim CD45, bright CD13, bright CD33 and dim CD117 positivity. 
      These were negative for CD34, HLA-DR, B-lymphoid and T-lymphoid lineage markers. 
      Conventional cytogenetics revealed a distinct karyotype of a male with 
      translocation t(4;15)(q34.2:q26.3). However, interphase fluorescence-in-situ 
      hybridization (FISH) revealed PML/RARA fusion signal on chromosome 15 in 90% 
      cells. The cryptic translocations may be missed on conventional cytogenetics, 
      however, need to be picked by other techniques as FISH.
FAU - Goyal, Manu
AU  - Goyal M
AD  - Department of Laboratory Medicine, Indo-American Cancer Institute and Research 
      Centre, Hyderabad, India. dr_manu31@yahoo.com
FAU - Dattatreya, Palinki S
AU  - Dattatreya PS
FAU - Goud, Irawathy
AU  - Goud I
FAU - Murthy, Sudha S
AU  - Murthy SS
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - India
TA  - Indian J Pathol Microbiol
JT  - Indian journal of pathology & microbiology
JID - 7605904
RN  - 0 (Antigens, CD)
RN  - 0 (HLA Antigens)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Promyelocytic Leukemia Protein)
RN  - 0 (RARA protein, human)
RN  - 0 (Receptors, Retinoic Acid)
RN  - 0 (Retinoic Acid Receptor alpha)
RN  - 0 (Transcription Factors)
RN  - 0 (Tumor Suppressor Proteins)
RN  - 143220-95-5 (PML protein, human)
SB  - IM
MH  - Antigens, CD/analysis
MH  - Cell Nucleus/genetics
MH  - Flow Cytometry
MH  - Gene Fusion
MH  - HLA Antigens/analysis
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Leukemia, Promyelocytic, Acute/*diagnosis/*pathology
MH  - Leukocytes/*cytology
MH  - Male
MH  - Middle Aged
MH  - Nuclear Proteins/genetics
MH  - Promyelocytic Leukemia Protein
MH  - Receptors, Retinoic Acid/genetics
MH  - Retinoic Acid Receptor alpha
MH  - Transcription Factors/genetics
MH  - Translocation, Genetic
MH  - Tumor Suppressor Proteins/genetics
EDAT- 2010/11/04 06:00
MHDA- 2011/02/04 06:00
CRDT- 2010/11/04 06:00
PHST- 2010/11/04 06:00 [entrez]
PHST- 2010/11/04 06:00 [pubmed]
PHST- 2011/02/04 06:00 [medline]
AID - IndianJPatholMicrobiol_2010_53_4_817_72097 [pii]
AID - 10.4103/0377-4929.72097 [doi]
PST - ppublish
SO  - Indian J Pathol Microbiol. 2010 Oct-Dec;53(4):817-9. doi: 
      10.4103/0377-4929.72097.