PMID- 21045429 OWN - NLM STAT- MEDLINE DCOM- 20110203 LR - 20101103 IS - 0974-5130 (Electronic) IS - 0377-4929 (Linking) VI - 53 IP - 4 DP - 2010 Oct-Dec TI - Critical evaluation of peripheral smear in cases of anemia with high mean corpuscular hemoglobin concentration in children: a series of four cases. PG - 820-3 LID - 10.4103/0377-4929.72094 [doi] AB - Mean corpuscular hemoglobin concentration (MCHC), a parameter that is reported as a part of a standard complete blood count by automated analyzer, is a measure of the concentration of hemoglobin in a given volume of packed red blood cell. Values of MCHC significantly above reference range are not physiologically possible due to limitations on solubility of hemoglobin. The high MCHC can give us a clue to certain type of hemolytic anemia and necessitate critical evaluation of peripheral smear to reach a definitive diagnosis. Here we are presenting a series of four cases with raised MCHC, emphasizing the importance of systematic and meticulous examination of the peripheral smear to render a definitive diagnosis. FAU - Sharma, Sunita AU - Sharma S AD - Department of Pathology, Lady Hardinge Medical College & Associated Hospitals, New Delhi - 110 001, India. FAU - Pujani, Meenu AU - Pujani M FAU - Pahuja, Sangeeta AU - Pahuja S FAU - Chandra, Jagdish AU - Chandra J FAU - Rath, B AU - Rath B CN - Labhchand LA - eng PT - Case Reports PT - Journal Article PL - India TA - Indian J Pathol Microbiol JT - Indian journal of pathology & microbiology JID - 7605904 SB - IM MH - Adolescent MH - Anemia, Hemolytic/*diagnosis/*pathology MH - Blood Cells/*cytology MH - Child MH - Child, Preschool MH - *Erythrocyte Indices MH - Female MH - Humans MH - Male MH - Microscopy MH - United States EDAT- 2010/11/04 06:00 MHDA- 2011/02/04 06:00 CRDT- 2010/11/04 06:00 PHST- 2010/11/04 06:00 [entrez] PHST- 2010/11/04 06:00 [pubmed] PHST- 2011/02/04 06:00 [medline] AID - IndianJPatholMicrobiol_2010_53_4_820_72094 [pii] AID - 10.4103/0377-4929.72094 [doi] PST - ppublish SO - Indian J Pathol Microbiol. 2010 Oct-Dec;53(4):820-3. doi: 10.4103/0377-4929.72094.