PMID- 21046139
OWN - NLM
STAT- MEDLINE
DCOM- 20110803
LR  - 20211020
IS  - 1439-6327 (Electronic)
IS  - 1439-6319 (Linking)
VI  - 111
IP  - 5
DP  - 2011 May
TI  - Exercise-associated hyponatremia: the influence of pre-exercise carbohydrate 
      status combined with high volume fluid intake on sodium concentrations and fluid 
      balance.
PG  - 797-807
LID - 10.1007/s00421-010-1706-1 [doi]
AB  - To evaluate the effect of hydration and carbohydrate (CHO) status on plasma 
      sodium, fluid balance, and regulatory factors (IL-6 & ADH) during and after 
      exercise; 10 males completed the following conditions: low CHO, euhydrated (fluid 
      intake = sweat loss) (LCEH); low CHO, dehydrated (no fluid) (LCDH); high CHO, 
      euhydrated (HCEH); and high CHO, dehydrated (HCDH). Each trial consisted of 
      90-min cycling at 60% VO(2) max in a 35 degrees C environment followed by 3-h rehydration 
      (RH). During RH, subjects received either 150% of sweat loss (LCDH & HCDH) or an 
      additional 50% of sweat loss (LCEH and HCEH). Blood was analyzed for glucose, 
      IL-6, ADH, and Na(+). Post-exercise Na(+) was greater (p < 0.001) for LCDH and 
      HCDH (141.7 + 0.72 and 141.6 + 0.4 mM) versus LCEH and HCEH (136.4 + 0.6 and 
      135.9 + 0.3 mM). Post-exercise IL-6 was similar in all conditions, and 
      post-exercise ADH was greater (p = 0.01) in dehydrated versus euhydrated 
      conditions. The rate of urine production was greater in HCEH (7.59 + 3.0 mL/min) 
      compared to all other conditions (3.86 + 2.2, 5.29 + 3.1, and 2.96 + 1.1 mL/min 
      for LCDH, LCEH, and HCDH, respectively). Despite CHO and hydration manipulations, 
      no regulatory effects of IL-6 and ADH on plasma [Na(+)] were observed. With 
      euhydration during exercise and additional fluid consumed during recovery, a 
      high-CHO status increased urinary output during recovery, and it decreased the 
      frequency of hyponatremia (Na(+) < 135 mM). Therefore, a high-CHO status may 
      provide some protection against exercise-associated hyponatremia.
FAU - Hubing, Kimberly A
AU  - Hubing KA
AD  - Exercise Physiology Laboratory, Texas Christian University, P.O. Box 297730, Fort 
      Worth, TX, 76129, USA.
FAU - Bassett, John T
AU  - Bassett JT
FAU - Quigg, Laura R
AU  - Quigg LR
FAU - Phillips, Melody D
AU  - Phillips MD
FAU - Barbee, James J
AU  - Barbee JJ
FAU - Mitchell, Joel B
AU  - Mitchell JB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101103
PL  - Germany
TA  - Eur J Appl Physiol
JT  - European journal of applied physiology
JID - 100954790
RN  - 0 (Dietary Carbohydrates)
RN  - 9NEZ333N27 (Sodium)
SB  - IM
MH  - Adult
MH  - Dietary Carbohydrates/*administration & dosage
MH  - Exercise/*physiology
MH  - Humans
MH  - Hyponatremia/*metabolism
MH  - Male
MH  - Sodium/blood
MH  - Water-Electrolyte Balance/*physiology
EDAT- 2010/11/04 06:00
MHDA- 2011/08/04 06:00
CRDT- 2010/11/04 06:00
PHST- 2010/10/19 00:00 [accepted]
PHST- 2010/11/04 06:00 [entrez]
PHST- 2010/11/04 06:00 [pubmed]
PHST- 2011/08/04 06:00 [medline]
AID - 10.1007/s00421-010-1706-1 [doi]
PST - ppublish
SO  - Eur J Appl Physiol. 2011 May;111(5):797-807. doi: 10.1007/s00421-010-1706-1. Epub 
      2010 Nov 3.