PMID- 21048807
OWN - NLM
STAT- MEDLINE
DCOM- 20110223
LR  - 20191111
IS  - 1804-7521 (Electronic)
IS  - 1213-8118 (Linking)
VI  - 154
IP  - 3
DP  - 2010 Sep
TI  - Potential role of selected biomarkers for predicting the presence and extent of 
      coronary artery disease.
PG  - 219-25
AB  - INTRODUCTION: Since atherosclerosis may in part be an inflammatory disease, 
      circulatory factors related to inflammation may be predictors of coronary artery 
      disease. The aim of this study was to evaluate the association between the level 
      of some circulating biomarkers and the extent of coronary artery disease. 
      METHODS: Blood samples were taken from 128 patients with stable forms of coronary 
      heart disease. Macrophage chemoattractant protein-1 (MCP-1), 
      matrix-metalloproteinase-3 (MMP-3), soluble CD40 ligand (sCD40L) and soluble 
      tumour necrosis factor receptor-2 (sTNFR2) were measured by ELISA. Coronary 
      angiography and grading with the SYNTAX score followed. RESULTS: There was no 
      significant interdependence of circulating MCP-1, sCD40L, sTNFR2 levels and 
      SYNTAX score. MMP-3 levels were significantly different in subgroup with coronary 
      artery disease (SYNTAX score > 0): 38.1 microg/l (13.6; 84.1) and subgroup without 
      coronary artery disease (SYNTAX score = 0): 20.4 microg/l (13.1; 82.8), p=0.001. 
      According to the Spearman correlation coefficient there was significant 
      association between MMP-3 level and SYNTAX score (0.358, a=0.05). CONCLUSIONS: 
      Our data suggest association between the extent of coronary artery disease and 
      circulating MMP-3. We failed to demonstrate any association with the other 
      investigated biomarkers.
FAU - Griva, Martin
AU  - Griva M
AD  - Department of Internal Medicine, T. Bata's Hospital, Zlin, Czech Republic. 
      m.griva@seznam.cz
FAU - Naplava, Robert
AU  - Naplava R
FAU - Spendlikova, Milada
AU  - Spendlikova M
FAU - Jarkovsky, Jiri
AU  - Jarkovsky J
FAU - Hlinomaz, Ota
AU  - Hlinomaz O
FAU - Cihalik, Cestmir
AU  - Cihalik C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Czech Republic
TA  - Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub
JT  - Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, 
      Czechoslovakia
JID - 101140142
RN  - 0 (Biomarkers)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Receptors, Tumor Necrosis Factor, Type II)
RN  - 147205-72-9 (CD40 Ligand)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers/*blood
MH  - CD40 Ligand/blood
MH  - Chemokine CCL2/blood
MH  - Coronary Artery Disease/blood/*diagnosis
MH  - Female
MH  - Humans
MH  - Male
MH  - Matrix Metalloproteinase 3/blood
MH  - Middle Aged
MH  - Receptors, Tumor Necrosis Factor, Type II/blood
EDAT- 2010/11/05 06:00
MHDA- 2011/02/24 06:00
CRDT- 2010/11/05 06:00
PHST- 2010/11/05 06:00 [entrez]
PHST- 2010/11/05 06:00 [pubmed]
PHST- 2011/02/24 06:00 [medline]
AID - 10.5507/bp.2010.033 [doi]
PST - ppublish
SO  - Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2010 Sep;154(3):219-25. doi: 
      10.5507/bp.2010.033.