PMID- 21049304
OWN - NLM
STAT- MEDLINE
DCOM- 20110628
LR  - 20220129
IS  - 1573-3297 (Electronic)
IS  - 0001-8244 (Print)
IS  - 0001-8244 (Linking)
VI  - 41
IP  - 1
DP  - 2011 Jan
TI  - Influence of candidate genes on attention problems in children: a longitudinal 
      study.
PG  - 155-64
LID - 10.1007/s10519-010-9406-5 [doi]
AB  - Attention problems form one of the core characteristics of Attention-Deficit 
      Hyperactive Disorder (ADHD), a multifactorial neurodevelopmental disorder. From 
      twin research it is clear that genes play a considerable role in the etiology and 
      in the stability of ADHD in childhood. Association studies have focused on genes 
      involved in the dopaminergic and serotoninergic systems, but with inconclusive 
      results. This study investigated the effect of 26 Single Nucleotide Polymorphisms 
      (SNPs) in genes encoding for serotonin receptors 2A (HTR2A), 
      Catechol-O-Methyltransferase (COMT), Tryptophane Hydroxylase type 2 (TPH2), and 
      Brain Derived Neurotrophic Factor (BDNF). Attention problems (AP) were assessed 
      by parental report at ages 3, 7, 10, and 12 years in more than 16,000 twin pairs. 
      There were 1148 genotyped children with AP data. We developed a longitudinal 
      framework to test the genetic association effect. Based on all phenotypic data, a 
      longitudinal model was formulated with one latent factor loading on all AP 
      measures over time. The broad heritability for the AP latent factor was 82%, and 
      the latent factor explained around 55% of the total phenotypic variance. The 
      association of SNPs with AP was then modeled at the level of this factor. None of 
      the SNPs showed a significant association with AP. The lowest p-value was found 
      for the rs6265 SNP in the BDNF gene (p = 0.035). Overall, our results suggest no 
      evidence for a role of these genes in childhood AP.
FAU - van Beijsterveldt, Catherina E M
AU  - van Beijsterveldt CE
AD  - Department of Biological Psychology, VU University Amsterdam, Van der 
      Boechorststraat 1, 1081 BT Amsterdam, The Netherlands. toos@psy.vu.nl
FAU - Middeldorp, Christel M
AU  - Middeldorp CM
FAU - Slof-Op't Landt, Margarita C T
AU  - Slof-Op't Landt MC
FAU - Bartels, Meike
AU  - Bartels M
FAU - Hottenga, Jouke-Jan
AU  - Hottenga JJ
FAU - Suchiman, H Eka D
AU  - Suchiman HE
FAU - Slagboom, P Eline
AU  - Slagboom PE
FAU - Boomsma, Dorret I
AU  - Boomsma DI
LA  - eng
GR  - R01 HL55976/HL/NHLBI NIH HHS/United States
GR  - DA-18673/DA/NIDA NIH HHS/United States
GR  - R01 DA018673/DA/NIDA NIH HHS/United States
GR  - R37 DA018673/DA/NIDA NIH HHS/United States
GR  - 230374/ERC_/European Research Council/International
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Twin Study
DEP - 20101030
PL  - United States
TA  - Behav Genet
JT  - Behavior genetics
JID - 0251711
SB  - IM
MH  - Alleles
MH  - Attention Deficit Disorder with Hyperactivity/*genetics
MH  - Child
MH  - Child, Preschool
MH  - Diseases in Twins/*genetics
MH  - Female
MH  - *Genetic Association Studies
MH  - Genotype
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Models, Genetic
MH  - Netherlands
MH  - Polymorphism, Single Nucleotide/genetics
PMC - PMC3029680
EDAT- 2010/11/05 06:00
MHDA- 2011/06/29 06:00
PMCR- 2010/10/30
CRDT- 2010/11/05 06:00
PHST- 2010/05/06 00:00 [received]
PHST- 2010/10/07 00:00 [accepted]
PHST- 2010/11/05 06:00 [entrez]
PHST- 2010/11/05 06:00 [pubmed]
PHST- 2011/06/29 06:00 [medline]
PHST- 2010/10/30 00:00 [pmc-release]
AID - 9406 [pii]
AID - 10.1007/s10519-010-9406-5 [doi]
PST - ppublish
SO  - Behav Genet. 2011 Jan;41(1):155-64. doi: 10.1007/s10519-010-9406-5. Epub 2010 Oct 
      30.